Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation

Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation

Bibliografiset tiedot
Parent link:ACS Applied Nano Materials.— .— Washington: American Chemical Society
Vol. 8, iss. 14.— 2025.— P. 6930-6942
Muut tekijät: Sharapova M. B. Marina, Zuev D. S. Daniil, Silvanovich E. K. Elizaveta, Ibraeva A. Zh. Azhar Zhangeldinovna, Morozova K. N. Ksenia, Kiseleva E. V. Elena, Chernozem P. V. Polina Viktorovna, Urakova A. O. Alina Olegovna, Wagner D. V. Dmitry, Gerasimov E. Yu. Evgeny, Shevelev O. B. Oleg, Sukhov B. G. Boris, Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich, Zavjalov E. L. Evgenii
Yhteenveto:Title screen
Nanotechnology-based approaches are increasingly recognized in cancer biology owing to their substantial impact on various tumor cells. Nanoparticles (NPs) can serve as carriers of nanoscale drug cargos and traverse neuronal cell membranes within the nasal cavity, thereby providing an effective means to bypass the blood–brain barrier, which otherwise limits the delivery of therapeutic agents to the brain. In this study, we investigated the feasibility of axonal trans-synaptic transport of MRI-sensitive magnetic MnFe2O4 (MFO) NPs from the nasal cavity to intracranially xenotransplanted glioblastoma in SCID mice. Using T1-weighted MRI, we mapped the distribution of MFO NPs and found that they accumulated in the tumor only when the glioblastoma was in direct contact with olfactory-system structures involved in nose-to-brain transport. Additionally, inhibition of axonal transport nearly abrogated the NP delivery to the tumor. Notably, olfactory-system stimulations via odor presentation significantly enhanced the nose-to-glioblastoma transport of MFO NPs. Thus, although neuronal interactions with cancer cells have detrimental effects, these interactions may also expand opportunities for targeted drug delivery during glioblastoma treatment
Текстовый файл
AM_Agreement
Kieli:englanti
Julkaistu: 2025
Aiheet:
magnetic nanoparticles
glioblastoma
olfactory stimulation
neuronal activity
manganese-enhanced MRI
nasal transport
neuron-to-glioma communication
targeted delivery
электронный ресурс
труды учёных ТПУ
Linkit:https://doi.org/10.1021/acsanm.4c07085
Aineistotyyppi: Elektroninen Kirjan osa
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=681226

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