Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation; ACS Applied Nano Materials; Vol. 8, iss. 14
| Parent link: | ACS Applied Nano Materials.— .— Washington: American Chemical Society Vol. 8, iss. 14.— 2025.— P. 6930-6942 |
|---|---|
| Další autoři: | , , , , , , , , , , , , , , |
| Shrnutí: | Title screen Nanotechnology-based approaches are increasingly recognized in cancer biology owing to their substantial impact on various tumor cells. Nanoparticles (NPs) can serve as carriers of nanoscale drug cargos and traverse neuronal cell membranes within the nasal cavity, thereby providing an effective means to bypass the blood–brain barrier, which otherwise limits the delivery of therapeutic agents to the brain. In this study, we investigated the feasibility of axonal trans-synaptic transport of MRI-sensitive magnetic MnFe2O4 (MFO) NPs from the nasal cavity to intracranially xenotransplanted glioblastoma in SCID mice. Using T1-weighted MRI, we mapped the distribution of MFO NPs and found that they accumulated in the tumor only when the glioblastoma was in direct contact with olfactory-system structures involved in nose-to-brain transport. Additionally, inhibition of axonal transport nearly abrogated the NP delivery to the tumor. Notably, olfactory-system stimulations via odor presentation significantly enhanced the nose-to-glioblastoma transport of MFO NPs. Thus, although neuronal interactions with cancer cells have detrimental effects, these interactions may also expand opportunities for targeted drug delivery during glioblastoma treatment Текстовый файл AM_Agreement |
| Jazyk: | angličtina |
| Vydáno: |
2025
|
| Témata: | |
| On-line přístup: | https://doi.org/10.1021/acsanm.4c07085 |
| Médium: | MixedMaterials Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=681226 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 681226 | ||
| 005 | 20251224103147.0 | ||
| 090 | |a 681226 | ||
| 100 | |a 20250819d2025 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a US | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i |b e | |
| 182 | 0 | |a b | |
| 183 | 0 | |a cr |2 RDAcarrier | |
| 200 | 1 | |a Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation |f Marina B. Sharapova, Daniil S. Zuev, Elizaveta K. Silvanovich [et al.] | |
| 203 | |a Текст |c электронный |b визуальный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 330 | |a Nanotechnology-based approaches are increasingly recognized in cancer biology owing to their substantial impact on various tumor cells. Nanoparticles (NPs) can serve as carriers of nanoscale drug cargos and traverse neuronal cell membranes within the nasal cavity, thereby providing an effective means to bypass the blood–brain barrier, which otherwise limits the delivery of therapeutic agents to the brain. In this study, we investigated the feasibility of axonal trans-synaptic transport of MRI-sensitive magnetic MnFe2O4 (MFO) NPs from the nasal cavity to intracranially xenotransplanted glioblastoma in SCID mice. Using T1-weighted MRI, we mapped the distribution of MFO NPs and found that they accumulated in the tumor only when the glioblastoma was in direct contact with olfactory-system structures involved in nose-to-brain transport. Additionally, inhibition of axonal transport nearly abrogated the NP delivery to the tumor. Notably, olfactory-system stimulations via odor presentation significantly enhanced the nose-to-glioblastoma transport of MFO NPs. Thus, although neuronal interactions with cancer cells have detrimental effects, these interactions may also expand opportunities for targeted drug delivery during glioblastoma treatment | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t ACS Applied Nano Materials |c Washington |n American Chemical Society | |
| 463 | 1 | |t Vol. 8, iss. 14 |v P. 6930-6942 |d 2025 | |
| 610 | 1 | |a magnetic nanoparticles | |
| 610 | 1 | |a glioblastoma | |
| 610 | 1 | |a olfactory stimulation | |
| 610 | 1 | |a neuronal activity | |
| 610 | 1 | |a manganese-enhanced MRI | |
| 610 | 1 | |a nasal transport | |
| 610 | 1 | |a neuron-to-glioma communication | |
| 610 | 1 | |a targeted delivery | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Sharapova |b M. B. |g Marina | |
| 701 | 1 | |a Zuev |b D. S. |g Daniil | |
| 701 | 1 | |a Silvanovich |b E. K. |g Elizaveta | |
| 701 | 1 | |a Ibraeva |b A. Zh. |g Azhar Zhangeldinovna |f 2000- |c biologist |c Laboratory assistant of Tomsk Polytechnic University |y Tomsk |9 88957 | |
| 701 | 1 | |a Morozova |b K. N. |g Ksenia | |
| 701 | 1 | |a Kiseleva |b E. V. |g Elena | |
| 701 | 1 | |a Chernozem |b P. V. |c specialist in the field of informatics and computer technology |c Research Engineer of Tomsk Polytechnic University |f 1997- |g Polina Viktorovna |9 22733 | |
| 701 | 1 | |a Urakova |b A. O. |c specialist in the field of material science |c Laboratory assistant of Tomsk Polytechnic University |f 2002- |g Alina Olegovna |9 88596 | |
| 701 | 1 | |a Wagner |b D. V. |g Dmitry | |
| 701 | 1 | |a Gerasimov |b E. Yu. |g Evgeny | |
| 701 | 1 | |a Shevelev |b O. B. |g Oleg | |
| 701 | 1 | |a Sukhov |b B. G. |g Boris | |
| 701 | 1 | |a Surmeneva |b M. A. |c specialist in the field of material science |c engineer-researcher of Tomsk Polytechnic University, Associate Scientist |f 1984- |g Maria Alexandrovna |9 15966 | |
| 701 | 1 | |a Surmenev |b R. A. |c physicist |c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences |f 1982- |g Roman Anatolievich |9 15957 | |
| 701 | 1 | |a Zavjalov |b E. L. |g Evgenii | |
| 801 | 0 | |a RU |b 63413507 |c 20250819 |g RCR | |
| 856 | 4 | |u https://doi.org/10.1021/acsanm.4c07085 |z https://doi.org/10.1021/acsanm.4c07085 | |
| 942 | |c CF | ||