The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth
| Parent link: | ACS Applied Materials & Interfaces.— .— Washington: American Chemical Society Vol. 17, iss. 14.— 2025.— P. 21614-21629 |
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| Diğer Yazarlar: | , , , , , , , , , , , , , , |
| Özet: | Title screen Magnetoelectric (ME) nanoparticles (NPs) exhibit strong coupling between magnetic and electric properties, enabling wireless control of biological processes through electromagnetic stimulation, which paves the way for diverse biomedical applications. However, the surface functionalization of ME NPs and its impact on their structure, physical properties, and biological response remain largely unexplored. In this study, biocompatible citric acid (CA) and pectin (PEC) were employed to functionalize quasi-spherical ME core–shell NPs comprising a magnetic spinel MnFe2O4 core (∼23 nm) and a ferroelectric perovskite Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) shell (∼5 nm), synthesized using microwave-assisted hydrothermal processing. The surface functionalization led to the formation of covalent bonds between CA and metal ions of NPs via chelation. The surface functionalization with PEC increased ζ-potential values of ME NPs up to −46.2 ± 0.6 mV compared to CA (25.3 ± 1.0 mV). Both MFO@BCZT NPs with CA and PEC exhibited low coercivity values (69 ± 5 and 29 ± 2 Oe, respectively) with a pronounced specific saturation magnetization (6.1 ± 0.2 and 5.2 ± 0.2 emu/g, respectively). No effect of the BCZT shell with subsequent CA (746 ± 22 Oe) and PEC (754 ± 23 Oe) surface functionalizations on the anisotropy field of ME NPs was observed compared to the pristine MFO cores (754 ± 23 Oe). Both CA-/PEC-functionalized MFO@BCZT NPs exhibited ferroelectric behavior with robust piezoresponse (9.95 ± 1.36 and 10.24 ± 2.03 pm/V, respectively) and high ME response (81 × 104 and 80 × 104 mV·cm–1·Oe–1, respectively), comparable to the most frequently studied Co-based analogs. In vitro assays demonstrated the ability of the developed ME NPs to control calcium flux, which enables bidirectional regulation of cell proliferation. This work advances the development of efficient and biocompatible ME NPs with promising applications in the noninvasive and targeted stimulation of cell behavior Текстовый файл AM_Agreement |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2025
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| Konular: | |
| Online Erişim: | https://doi.org/10.1021/acsami.4c21337 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=681222 |
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| 200 | 1 | |a The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth |f Polina V. Chernozem, Alexander V. Romashchenko, Olga I. Solovieva [et al.] | |
| 203 | |a Текст |c электронный |b визуальный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 86 tit | ||
| 330 | |a Magnetoelectric (ME) nanoparticles (NPs) exhibit strong coupling between magnetic and electric properties, enabling wireless control of biological processes through electromagnetic stimulation, which paves the way for diverse biomedical applications. However, the surface functionalization of ME NPs and its impact on their structure, physical properties, and biological response remain largely unexplored. In this study, biocompatible citric acid (CA) and pectin (PEC) were employed to functionalize quasi-spherical ME core–shell NPs comprising a magnetic spinel MnFe2O4 core (∼23 nm) and a ferroelectric perovskite Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) shell (∼5 nm), synthesized using microwave-assisted hydrothermal processing. The surface functionalization led to the formation of covalent bonds between CA and metal ions of NPs via chelation. The surface functionalization with PEC increased ζ-potential values of ME NPs up to −46.2 ± 0.6 mV compared to CA (25.3 ± 1.0 mV). Both MFO@BCZT NPs with CA and PEC exhibited low coercivity values (69 ± 5 and 29 ± 2 Oe, respectively) with a pronounced specific saturation magnetization (6.1 ± 0.2 and 5.2 ± 0.2 emu/g, respectively). No effect of the BCZT shell with subsequent CA (746 ± 22 Oe) and PEC (754 ± 23 Oe) surface functionalizations on the anisotropy field of ME NPs was observed compared to the pristine MFO cores (754 ± 23 Oe). Both CA-/PEC-functionalized MFO@BCZT NPs exhibited ferroelectric behavior with robust piezoresponse (9.95 ± 1.36 and 10.24 ± 2.03 pm/V, respectively) and high ME response (81 × 104 and 80 × 104 mV·cm–1·Oe–1, respectively), comparable to the most frequently studied Co-based analogs. In vitro assays demonstrated the ability of the developed ME NPs to control calcium flux, which enables bidirectional regulation of cell proliferation. This work advances the development of efficient and biocompatible ME NPs with promising applications in the noninvasive and targeted stimulation of cell behavior | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t ACS Applied Materials & Interfaces |c Washington |n American Chemical Society | |
| 463 | 1 | |t Vol. 17, iss. 14 |v P. 21614-21629 |d 2025 | |
| 610 | 1 | |a magnetoelectrics | |
| 610 | 1 | |a magnetic materials | |
| 610 | 1 | |a core−shell nanoparticles | |
| 610 | 1 | |a surface functionalization | |
| 610 | 1 | |a neuronal stimulation | |
| 610 | 1 | |a cancer treatment | |
| 610 | 1 | |a noninvasive electrostimulation | |
| 610 | 1 | |a biomodal cell growth | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Chernozem |b P. V. |c specialist in the field of informatics and computer technology |c Research Engineer of Tomsk Polytechnic University |f 1997- |g Polina Viktorovna |9 22733 | |
| 701 | 1 | |a Romashchenko |b A. V. |g Aleksandr Viktorovich |f 1986- |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |x TPU |y Томск |9 88955 | |
| 701 | 1 | |a Solovieva |b O. I. |g Olga | |
| 701 | 1 | |a Ibraeva |b A. Zh. |g Azhar Zhangeldinovna |f 2000- |c biologist |c Laboratory assistant of Tomsk Polytechnic University |y Tomsk |9 88957 | |
| 701 | 1 | |a Nosov |b G. |g Georgy | |
| 701 | 1 | |a Koptsev |b D. A. |c specialist in the field of material science |c Laboratory assistant of Tomsk Polytechnic University |f 2003- |g Danila Andreevich |9 88597 | |
| 701 | 1 | |a Lisitsyn |b S. |g Sergey | |
| 701 | 1 | |a Surmeneva |b M. A. |c specialist in the field of material science |c engineer-researcher of Tomsk Polytechnic University, Associate Scientist |f 1984- |g Maria Alexandrovna |9 15966 | |
| 701 | 1 | |a Vagner |b D. |g Dmitry | |
| 701 | 1 | |a Gerasimov |b E. Yu. |g Evgeny | |
| 701 | 1 | |a Kazantsev |b S. O. |c specialist in the field of material science |c engineer of Tomsk Polytechnic University |f 1991- |g Sergey Olegovich |9 18951 | |
| 701 | 1 | |a Lozhkomoev |b A. S. |c specialist in the field of medical technology |c researcher of Tomsk Polytechnic University |f 1982- |g Aleksandr Sergeevich |9 18056 | |
| 701 | 1 | |a Sukhorukov |b G. B. |c chemist |c The Head of the Laboratory of Tomsk Polytechnic University, Candidate of physical and mathematical sciences |f 1969- |g Gleb Borisovich |9 20271 | |
| 701 | 1 | |a Surmenev |b R. A. |c physicist |c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences |f 1982- |g Roman Anatolievich |9 15957 | |
| 701 | 1 | |a Chernozem |b R. V. |c physicist |c Associate Professor of Tomsk Polytechnic University |f 1992- |g Roman Viktorovich |9 19499 | |
| 801 | 0 | |a RU |b 63413507 |c 20250818 |g RCR | |
| 856 | 4 | |u https://doi.org/10.1021/acsami.4c21337 |z https://doi.org/10.1021/acsami.4c21337 | |
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