Argovit™ Silver Nanoparticles Mitigate Sodium Arsenite-Induced Cytogenotoxicity Effects in Cultured Human Lymphocytes

Argovit™ Silver Nanoparticles Mitigate Sodium Arsenite-Induced Cytogenotoxicity Effects in Cultured Human Lymphocytes

Bibliographic Details
Parent link:Toxics.— .— Basel: MDPI AG
Vol. 13, iss. 7.— 2025.— Article number 539, 17 p.
Other Authors: del Carmen Jauregui R. M. Romo Maria, Ruiz-Ruiz B. Balam, Casilias-Figueroa F. Francisco, Guadalupe Giron V. N. Vazquez Nayeli, Roberto Luna V. G. Vazquez Gomez, Torres-Bugarin O. Olivia, Castaneda-Yslas I. Ya. Idalia Yazmin, Pestryakov A. N. Aleksey Nikolaevich, Bogdanchikova N. Nina, Arellano-Garcia M. E. Maria Evarista
Summary:Title screen
Exposure to arsenic, a known environmental and occupational genotoxicant, poses significant health risks. Identifying agents capable of mitigating its effects is crucial for public health. This study evaluates the protective potential of Argovit™ silver nanoparticles (AgNPs) against cytotoxic and genotoxic damage induced by sodium arsenite in ex vivo cultured human lymphocytes obtained from the whole blood of healthy donors. Lymphocytes were exposed to sodium arsenite (3.7 × 10−3 µg/mL) and Argovit™ AgNPs (3.6 × 10−3 µg/mL). The cytokinesis-block micronucleus (CBMN) assay was performed using a modified 144 h protocol to assess delayed effects across two cell cycles. Four groups were analyzed: untreated control, sodium arsenite only, AgNPs only, and sodium arsenite followed by AgNPs. Arsenite exposure increased cytotoxic and genotoxic biomarkers. In contrast, post-treatment with AgNPs significantly reduced these effects. All treatments were performed in duplicate, and data were analyzed using the Kruskal–Wallis test with Dunn’s post hoc comparison (p < 0.05). Statistical analysis confirmed the antigenotoxic and cytoprotective properties of Argovit™. These findings support its potential application as a mitigating agent in scenarios of environmental or occupational exposure to genotoxic compounds
Текстовый файл
Language:English
Published: 2025
Subjects:
cytotogenotoxicity
lymphocytes culture
silver nanoparticles
труды учёных ТПУ
электронный ресурс
Online Access:https://doi.org/10.3390/toxics13070539
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=681220

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