Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy; Polymers; Vol. 17, iss. 11

Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy; Polymers; Vol. 17, iss. 11

Detalles Bibliográficos
Parent link:Polymers.— .— Basel: MDPI AG
Vol. 17, iss. 11.— 2025.— Article number 1514, 22 p.
Otros Autores: Mieszkowska A. Anna, Martocq L. Laurine, Koptyug A. Andrey, Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich, Naderi J. Javad, Muchova M. Maria, Gurzawska-Comis K. A. Katarzyna, Douglas T. E. L. Timothy
Sumario:Title screen
Biomaterials play a crucial role in the long-term success of bone implant treatment. The accumulation of bacterial biofilm on the implants induces inflammation, leading to implant failure. Modification of the implant surface with bioactive molecules is one of the strategies to improve biomaterial compatibility and limit inflammation. In this study, whey protein isolate (WPI) fibrillar coatings were used as a matrix to incorporate biologically active phenolic compound phloroglucinol (PG) at different concentrations (0.1% and 0.5%) on titanium alloy (Ti6Al4V) scaffolds. Successful Ti6Al4V coatings were validated by X-ray photoelectron spectroscopy (XPS), showing a decrease in %Ti and increases in %C, %N, and %O, which demonstrate the presence of the protein layer. The biological activity of PG-enriched WPI (WPI/PG) coatings was assessed using bone-forming cells, human bone marrow-derived mesenchymal stem cells (BM-MSCs). WPI/PG coatings modulated the behavior of BM-MSCs but did not have a negative impact on cell viability. A WPI with higher concentrations of PG increased gene expression relative to osteogenesis and reduced the pro-inflammatory response of BM-MSCs after biofilm stimulation. Autoclaving reduced WPI/PG bioactivity compared to filtration. By using WPI/PG coatings, this study addresses the challenge of improving osteogenic potential while limiting biofilm-induced inflammation at the Ti6Al4V surface. These coatings represent a promising strategy to enhance implant bioactivity
Текстовый файл
Lenguaje:inglés
Publicado: 2025
Materias:
электронный ресурс
труды учёных ТПУ
Ti6Al4V
fibrillar coating
phenolic coating
whey protein isolate
inflammation; biofilm
osseointegration
osteogenesis
stem cells
Acceso en línea:https://doi.org/10.3390/polym17111514
Formato: Electrónico Capítulo de libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680825

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