The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain

The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain

Bibliographic Details
Parent link:Neurochemical Journal=Нейрохимия.— .— Cham: Springer International Publishing
Vol. 17, iss. 3.— 2023.— P. 369–379
Other Authors: Zhdankina A. A. Anna Aleksandrovna, Osipenko A. N. Anton Nikolaevich, Tikhonov D. I., Logvinov S. V. Sergey Valentinovich, Plotnikov M. B. Mark Borisovich, Khlebnikov A. I. Andrey Ivanovich, Kolosova M. G. Nataliya Gorislavovna
Summary:Title screen
According to the Alzheimer’s Disease International (ADI) international organization about 50 million people in the world suffer from Alzheimer’s disease (AD). However, there are no effective methods for preventing or slowing the progression of AD. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway is discussed below as an alternative way to prevent the development of AD and other neurodegenerative diseases. In the present study, we evaluated the ability of a recently synthesized selective JNK3 inhibitor, 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), to suppress neurodegenerative processes in OXYS rats at an early stage of development of AD at the ages of 4.5 to 6 months. Treatment with IQ-1S (50 mg/kg intragastrically) led to the suppression of the development of neurodegenerative processes in the cerebral cortex of OXYS rats: an increase in the proportion of unchanged neurons, a decrease in the proportion of neurons with signs of destruction and irreversible damage, and a normalization of the glioneuronal index, which was facilitated by a decrease in the severity of hyperviscosity syndrome blood in OXYS rats. The use of the IQ-1S JNK3 inhibitor may be a promising strategy for the prevention of early neurodegenerative disorders and, possibly, the treatment of AD
Текстовый файл
AM_Agreement
Language:English
Published: 2023
Subjects:
brain aging
neurodegeneration
OXYS rats
JNK inhibitor
11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt
hemorheology
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1134/S1819712423030212
Статья на русском языке
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680410

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