Effect of PLGA Concentration in Electrospinning Solution on Biocompatibility, Morphology and Mechanical Properties of Nonwoven Scaffolds; Technologies; Vol. 11, iss. 5

Effect of PLGA Concentration in Electrospinning Solution on Biocompatibility, Morphology and Mechanical Properties of Nonwoven Scaffolds; Technologies; Vol. 11, iss. 5

Dades bibliogràfiques
Parent link:Technologies.— .— Basel: MDPI AG
Vol. 11, iss. 5.— 2023.— Article number 137, 22 p.
Altres autors: Badaraev A. D. Arsalan Dorzhievich, Tran Tuan Hoang, Drozd A. G. Anastasiya Gennadjevna, Plotnikov E. V. Evgeny Vladimirovich, Dubinenko G. E. Gleb Evgenjevich, Kozelskaya A. I. Anna Ivanovna, Rutkowski S. Sven, Tverdokhlebov S. I. Sergei Ivanovich
Sumari:Title screen
In this work, the effects of weight concentration on the properties of poly(lactide-co-glycolide) polymeric scaffolds prepared by electrospinning are investigated, using four different weight concentrations of poly(lactide-co-glycolide) for the electrospinning solutions (2, 3, 4, 5 wt.%). With increasing concentration of poly(lactide-co-glycolide) in the electrospinning solutions, their viscosity increases significantly. The average fiber diameter of the scaffolds also increases with increasing concentration. Moreover, the tensile strength and maximum elongation at break of the scaffold increase with increasing electrospinning concentration. The prepared scaffolds have hydrophobic properties and their wetting angle does not change with the concentration of the electrospinning solution. All poly(lactide-co-glycolide) scaffolds are non-toxic toward fibroblasts of the cell line 3T3-L1, with the highest numbers of cells observed on the surface of scaffolds prepared from the 2-, 3- and 4-wt.% electrospinning solutions. The results of the analysis of mechanical and biological properties indicate that the poly(lactide-co-glycolide) scaffolds prepared from the 4 wt.% electrospinning solution have optimal properties for future applications in skin tissue engineering. This is due to the fact that the poly(lactide-co-glycolide) scaffolds prepared from the 2 wt.% and 3 wt.% electrospinning solution exhibit low mechanical properties, and 5 wt.% have the lowest porosity values, which might be the cause of their lowest biological properties
Текстовый файл
Idioma:anglès
Publicat: 2023
Matèries:
electrospinning
PLGA scaffolds
polymer concentration
biocompatibility
degradation
электронный ресурс
труды учёных ТПУ
Accés en línia:http://earchive.tpu.ru/handle/11683/132509
https://doi.org/10.3390/technologies11050137
Format: Electrònic Capítol de llibre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680200

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