Effect of PLGA Concentration in Electrospinning Solution on Biocompatibility, Morphology and Mechanical Properties of Nonwoven Scaffolds
| Parent link: | Technologies.— .— Basel: MDPI AG Vol. 11, iss. 5.— 2023.— Article number 137, 22 p. |
|---|---|
| Autres auteurs: | , , , , , , , |
| Résumé: | Title screen In this work, the effects of weight concentration on the properties of poly(lactide-co-glycolide) polymeric scaffolds prepared by electrospinning are investigated, using four different weight concentrations of poly(lactide-co-glycolide) for the electrospinning solutions (2, 3, 4, 5 wt.%). With increasing concentration of poly(lactide-co-glycolide) in the electrospinning solutions, their viscosity increases significantly. The average fiber diameter of the scaffolds also increases with increasing concentration. Moreover, the tensile strength and maximum elongation at break of the scaffold increase with increasing electrospinning concentration. The prepared scaffolds have hydrophobic properties and their wetting angle does not change with the concentration of the electrospinning solution. All poly(lactide-co-glycolide) scaffolds are non-toxic toward fibroblasts of the cell line 3T3-L1, with the highest numbers of cells observed on the surface of scaffolds prepared from the 2-, 3- and 4-wt.% electrospinning solutions. The results of the analysis of mechanical and biological properties indicate that the poly(lactide-co-glycolide) scaffolds prepared from the 4 wt.% electrospinning solution have optimal properties for future applications in skin tissue engineering. This is due to the fact that the poly(lactide-co-glycolide) scaffolds prepared from the 2 wt.% and 3 wt.% electrospinning solution exhibit low mechanical properties, and 5 wt.% have the lowest porosity values, which might be the cause of their lowest biological properties Текстовый файл |
| Langue: | anglais |
| Publié: |
2023
|
| Sujets: | |
| Accès en ligne: | http://earchive.tpu.ru/handle/11683/132509 https://doi.org/10.3390/technologies11050137 |
| Format: | Électronique Chapitre de livre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680200 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 680200 | ||
| 005 | 20250917142843.0 | ||
| 090 | |a 680200 | ||
| 100 | |a 20250514d2023 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a CH | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i |b e | |
| 182 | 0 | |a b | |
| 183 | 0 | |a cr |2 RDAcarrier | |
| 200 | 1 | |a Effect of PLGA Concentration in Electrospinning Solution on Biocompatibility, Morphology and Mechanical Properties of Nonwoven Scaffolds |f Arsalan D. Badaraev, Tuan-Hoang Tran, Anastasia G. Drozd [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 81 tit | ||
| 330 | |a In this work, the effects of weight concentration on the properties of poly(lactide-co-glycolide) polymeric scaffolds prepared by electrospinning are investigated, using four different weight concentrations of poly(lactide-co-glycolide) for the electrospinning solutions (2, 3, 4, 5 wt.%). With increasing concentration of poly(lactide-co-glycolide) in the electrospinning solutions, their viscosity increases significantly. The average fiber diameter of the scaffolds also increases with increasing concentration. Moreover, the tensile strength and maximum elongation at break of the scaffold increase with increasing electrospinning concentration. The prepared scaffolds have hydrophobic properties and their wetting angle does not change with the concentration of the electrospinning solution. All poly(lactide-co-glycolide) scaffolds are non-toxic toward fibroblasts of the cell line 3T3-L1, with the highest numbers of cells observed on the surface of scaffolds prepared from the 2-, 3- and 4-wt.% electrospinning solutions. The results of the analysis of mechanical and biological properties indicate that the poly(lactide-co-glycolide) scaffolds prepared from the 4 wt.% electrospinning solution have optimal properties for future applications in skin tissue engineering. This is due to the fact that the poly(lactide-co-glycolide) scaffolds prepared from the 2 wt.% and 3 wt.% electrospinning solution exhibit low mechanical properties, and 5 wt.% have the lowest porosity values, which might be the cause of their lowest biological properties | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Technologies |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 11, iss. 5 |v Article number 137, 22 p. |d 2023 | |
| 610 | 1 | |a electrospinning | |
| 610 | 1 | |a PLGA scaffolds | |
| 610 | 1 | |a polymer concentration | |
| 610 | 1 | |a biocompatibility | |
| 610 | 1 | |a degradation | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Badaraev |b A. D. |c Physicist |c Engineer of Tomsk Polytechnic University |f 1995- |g Arsalan Dorzhievich |9 22441 | |
| 701 | 0 | |a Tran Tuan Hoang |c specialist in the field of nuclear technologies |c engineer of Tomsk Polytechnic University |f 1993- |9 23068 | |
| 701 | 1 | |a Drozd |b A. G. |g Anastasiya Gennadjevna | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |9 16417 | |
| 701 | 1 | |a Dubinenko |b G. E. |c Specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1992- |g Gleb Evgenjevich |9 21551 | |
| 701 | 1 | |a Kozelskaya |b A. I. |c physicist |c Researcher at Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences |f 1985- |g Anna Ivanovna |9 21044 | |
| 701 | 1 | |a Rutkowski |b S. |c chemist |c Research Engineer, Tomsk Polytechnic University, Ph.D |f 1981- |g Sven |9 22409 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |9 15101 | |
| 801 | 0 | |a RU |b 63413507 |c 20250514 | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/132509 |z http://earchive.tpu.ru/handle/11683/132509 | |
| 856 | 4 | |u https://doi.org/10.3390/technologies11050137 |z https://doi.org/10.3390/technologies11050137 | |
| 942 | |c CF | ||