Copper-catalyzed N-arylation of 1,2,4-oxadiazin-5(6H)-ones by diaryliodonium salts; Organic and Biomolecular Chemistry; Vol. 23, iss. 17

Copper-catalyzed N-arylation of 1,2,4-oxadiazin-5(6H)-ones by diaryliodonium salts; Organic and Biomolecular Chemistry; Vol. 23, iss. 17

Bibliografski detalji
Parent link:Organic and Biomolecular Chemistry.— .— London: Royal Society of Chemistry
Vol. 23, iss. 17.— 2025.— P. 4217-4225
Daljnji autori: Presnukhina S. I. Sofia, Baykova S. O. Svetlana, Chukanova E. A. Elizaveta, Metalnikova N. M. Nadezhda Maksimovna, Baykov S. V. Sergey, Soldatova N. S. Nataliya Sergeevna, Postnikov P. S. Pavel Sergeevich, Boyarskiy V. P. Vadim
Sažetak:Herein, we developed a new synthetic approach for the preparation of N-arylated 1,2,4-oxadiazin-5(6H)-ones by direct arylation with diaryliodonium salts. The reaction with symmetrical diaryliodonium salts using CuI as a catalyst proceeded in toluene in the presence of DIPEA at 60 °C with the formation of the desired products in isolated yields of 46 to 97% (20 examples). The use of more readily available unsymmetrical diaryliodonium salts required higher reaction temperatures (up to 100 °C) to achieve similar yields. The only limitation observed in reaction was with an ortho-substituted iodonium salt. In all other cases, the developed approach allowed the preparation of a broad range of N-arylated 1,2,4-oxadiazin-5(6H)-ones under mild conditions utilizing a cheap and readily available catalyst
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AM_Agreement
Jezik:engleski
Izdano: 2025
Teme:
труды учёных ТПУ
электронный ресурс
Online pristup:https://doi.org/10.1039/D5OB00204D
Format: Elektronički Poglavlje knjige
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680065

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