Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds

Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds

Dades bibliogràfiques
Parent link:Journal of Pharmaceutical Sciences.— .— Amsterdam: Elsevier Science Publishing Company Inc.
Vol. 112, iss. 11.— 2023.— P. 2752-2755
Altres autors: Goreninsky (Goreninskii) S. I. Semen Igorevich, Volokhova A. A. Apollinariya Aleksandrovna, Frolova A. A. Anastasiya Aleksandrovna, Buldakov M. A. Mikhail Aleksandrovich, Cherdyntseva N. V. Nadezhda Viktorovna, Choynzonov E. L. Evgeny Lkhamatsyrenovich, Sudarev E. A. Evgeniy Aleksandrovich, Filimonov V. D. Viktor Dmitrievich, Tverdokhlebov S. I. Sergei Ivanovich, Bolbasov E. N. Evgeny Nikolaevich
Sumari:Title screen
Burst release, typical for the drug-loaded electrospun poly(ε-caprolactone) (PCL) scaffolds is unfavorable in case of cytostatics due to the toxic levels reached during the initial implantation period. In the present short communication, we report an unexpected ability of the composite scaffolds made of PCL and water-soluble polyvinylpyrrolidone (PVP) to provide long-term release of widely used anti-cancer drug doxorubicin hydrochloride (DOX-HCl). That effect was observed for electrospun DOX-HCl-loaded composite scaffolds based on PCL and PVP with various mass ratios (100/0, 95/5, 90/10, 75/25 and 50/50). After the morphology and water contact angle studies, it was concluded that PVP content has no effect on the average fiber diameter, while PVP content higher 10 wt. % changes the hydrophobic character of the scaffolds surface (water contact angle of 123.9 ± 3.5°) to superhydrophilic (water contact angle of 0°). Despite the dramatic change in water wettability, by high performance liquid chromatography (HPLC), it was revealed that the PVP content in the scaffolds reduces the DOX-HCl release rate under short (first hours) and long-term (during 1 month) exposure to phosphate buffer saline (PBS). These results are in good agreement with in vitro studies, in which the viability of HeLa cervical cancer cells was higher after 24 h of culture with scaffolds with high PVP content
Текстовый файл
AM_Agreement
Idioma:anglès
Publicat: 2023
Matèries:
электронный ресурс
труды учёных ТПУ
Accés en línia:https://doi.org/10.1016/j.xphs.2023.08.025
Format: Electrònic Capítol de llibre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680044

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