Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds
| Parent link: | Journal of Pharmaceutical Sciences.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 112, iss. 11.— 2023.— P. 2752-2755 |
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| Άλλοι συγγραφείς: | , , , , , , , , , |
| Περίληψη: | Title screen Burst release, typical for the drug-loaded electrospun poly(ε-caprolactone) (PCL) scaffolds is unfavorable in case of cytostatics due to the toxic levels reached during the initial implantation period. In the present short communication, we report an unexpected ability of the composite scaffolds made of PCL and water-soluble polyvinylpyrrolidone (PVP) to provide long-term release of widely used anti-cancer drug doxorubicin hydrochloride (DOX-HCl). That effect was observed for electrospun DOX-HCl-loaded composite scaffolds based on PCL and PVP with various mass ratios (100/0, 95/5, 90/10, 75/25 and 50/50). After the morphology and water contact angle studies, it was concluded that PVP content has no effect on the average fiber diameter, while PVP content higher 10 wt. % changes the hydrophobic character of the scaffolds surface (water contact angle of 123.9 ± 3.5°) to superhydrophilic (water contact angle of 0°). Despite the dramatic change in water wettability, by high performance liquid chromatography (HPLC), it was revealed that the PVP content in the scaffolds reduces the DOX-HCl release rate under short (first hours) and long-term (during 1 month) exposure to phosphate buffer saline (PBS). These results are in good agreement with in vitro studies, in which the viability of HeLa cervical cancer cells was higher after 24 h of culture with scaffolds with high PVP content Текстовый файл AM_Agreement |
| Γλώσσα: | Αγγλικά |
| Έκδοση: |
2023
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| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1016/j.xphs.2023.08.025 |
| Μορφή: | Ηλεκτρονική πηγή Κεφάλαιο βιβλίου |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680044 |
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| 200 | 1 | |a Prolonged and Controllable Release of Doxorubicin Hydrochloride from the Composite Electrospun Poly(ε-Caprolactone)/Polyvinylpyrrolidone Scaffolds |f Semen Goreninskii, Apollinariya Volokhova, Anastasia Frolova [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 21 tit | ||
| 330 | |a Burst release, typical for the drug-loaded electrospun poly(ε-caprolactone) (PCL) scaffolds is unfavorable in case of cytostatics due to the toxic levels reached during the initial implantation period. In the present short communication, we report an unexpected ability of the composite scaffolds made of PCL and water-soluble polyvinylpyrrolidone (PVP) to provide long-term release of widely used anti-cancer drug doxorubicin hydrochloride (DOX-HCl). That effect was observed for electrospun DOX-HCl-loaded composite scaffolds based on PCL and PVP with various mass ratios (100/0, 95/5, 90/10, 75/25 and 50/50). After the morphology and water contact angle studies, it was concluded that PVP content has no effect on the average fiber diameter, while PVP content higher 10 wt. % changes the hydrophobic character of the scaffolds surface (water contact angle of 123.9 ± 3.5°) to superhydrophilic (water contact angle of 0°). Despite the dramatic change in water wettability, by high performance liquid chromatography (HPLC), it was revealed that the PVP content in the scaffolds reduces the DOX-HCl release rate under short (first hours) and long-term (during 1 month) exposure to phosphate buffer saline (PBS). These results are in good agreement with in vitro studies, in which the viability of HeLa cervical cancer cells was higher after 24 h of culture with scaffolds with high PVP content | ||
| 336 | |a Текстовый файл | ||
| 371 | |a AM_Agreement | ||
| 461 | 1 | |t Journal of Pharmaceutical Sciences |c Amsterdam |n Elsevier Science Publishing Company Inc. | |
| 463 | 1 | |t Vol. 112, iss. 11 |v P. 2752-2755 |d 2023 | |
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| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Goreninsky (Goreninskii) |b S. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1993- |g Semen Igorevich |9 21234 | |
| 701 | 1 | |a Volokhova |b A. A. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1995- |g Apollinariya Aleksandrovna |9 88476 | |
| 701 | 1 | |a Frolova |b A. A. |g Anastasiya Aleksandrovna | |
| 701 | 1 | |a Buldakov |b M. A. |g Mikhail Aleksandrovich | |
| 701 | 1 | |a Cherdyntseva |b N. V. |g Nadezhda Viktorovna | |
| 701 | 1 | |a Choynzonov |b E. L. |c physicist |c chief expert of Tomsk Polytechnic University |f 1952- |g Evgeny Lkhamatsyrenovich |9 17937 | |
| 701 | 1 | |a Sudarev |b E. A. |g Evgeniy Aleksandrovich |f 1986- |c Chemical Engineer |c Associate Professor of Tomsk Polytechnic University, Candidate of technical Sciences |9 17981 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |9 12127 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |9 15101 | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |9 15103 | |
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