Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation; Molecules; Vol. 30, iss. 1

Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation; Molecules; Vol. 30, iss. 1

書目詳細資料
Parent link:	Molecules.— .— Basel: MDPI AG Vol. 30, iss. 1.— 2025.— Article number 117, 17 p.
其他作者:	Popov A. Alexander, Suvorov N. Nikita, Larkina M. S. Mariya Sergeevna, Plotnikov E. V. Evgeny Vladimirovich, Varvashenya R. N. Ruslan Nikolaevich, Bodenko V. V. Vitalina Vasiljevna, Yanovich G. Gleb, Ostroverkhov P. Petr, Usachev M. Maxim, Filonenko E. Elena, Belousov M. V. Mikhail Valerjevich, Grin M. Mikhail
總結:	Title screen The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, 99mTc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective 99mTc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with 99mTc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with 99mTc Текстовый файл
語言:	英语
出版:	2025
主題:	электронный ресурс труды учёных ТПУ technetium-99m chlorin radiopharmaceuticals HYNIC cancer
在線閱讀:	http://earchive.tpu.ru/handle/11683/132443 https://doi.org/10.3390/molecules30010117
格式:	電子 Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679724

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