Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study Author links open overlay panel

Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study Author links open overlay panel

Détails bibliographiques
Parent link:	Nanomedicine: Nanotechnology, Biology and Medicine.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 65.— 2025.— Article number 102813, 11 p.
Autres auteurs:	Plotnikov E. V. Evgeny Vladimirovich, Drozd A. G. Anastasiya Gennadjevna, Artamonov A. A., Larkina M. S. Mariya Sergeevna, Belousov M. V. Mikhail Valerievich, Lomov I. V. Ivan Viktorovich, Garibo D. Diana, Pestryakov A. N. Aleksey Nikolaevich, Bogdanchikova N. Nina
Résumé:	Title screen Growing interest in cancer radiotherapy has led to the application of nanoparticles as radiosensitizers. Here, we, for the first time, present the results of the radiosensitizing properties of silver nanoparticles (AgNPs) (possessing low toxicity towards human body) against cancer cells under neutron irradiation. Five standard cancer cultures (including glioblastoma, known for its resistance to conventional photon radiation) were used to evaluate the radiosensitizing properties of AgNPs suing MTT test, flow cytometry, and optical fluorescence microscopy. Neutron irradiation was applied in the absorbed dose of 0.5–1.5 Gy with an average neutron energy of 7.5 MeV. AgNPs increased the irradiation efficiency with the radiosensitivity enhancement ratios 1.02–2.32, for glioblastoma with ratios 1.22–1.47. It was revealed that at 1.5 Gy, AgNP-induced cytotoxicity made a significant contribution to the total observed radiosensitizer effect: on average, for five cell types, 29.8 and 96.2 % at the AgNP concentration of 0.2 and 1.6 μg/mL, respectively Текстовый файл AM_Agreement
Langue:	anglais
Publié:	2025
Sujets:	электронный ресурс труды учёных ТПУ Neutron irradiation Radiosensitization Cytotoxicity Silver nanoparticles Tumor cells
Accès en ligne:	https://doi.org/10.1016/j.nano.2025.102813
Format:	Électronique Chapitre de livre
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679535

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