Antiviral Activity of (1S,9aR)-1-[(1,2,3-Triazol-1-yl)methyl]octahydro-1H-quinolizines from the Alkaloid Lupinine

Antiviral Activity of (1S,9aR)-1-[(1,2,3-Triazol-1-yl)methyl]octahydro-1H-quinolizines from the Alkaloid Lupinine

Detaylı Bibliyografya
Parent link:Molecules.— .— Basel: MDPI AG
Vol. 29, iss. 23.— 2024.— Article number 5742, 15 p.
Diğer Yazarlar: Nurmaganbetov Zh. S. Zhangeldy, Nurkenov O. A. Oralgazy, Khlebnikov A. I. Andrey Ivanovich, Fazylov S. D. Serik, Seidakhmetova R. B. Roza, Tukhmetova Zh. K. Zhanar, Takibayeva A. T. Altynaray, Khabdolda G. Gaukhar, Rakhimberlinova Zh. B. Zhanar, Kaldybayeva A. K. Aigul, Shults E. E. Elvira
Özet:Title screen
Influenza is a disease of significant morbidity and mortality. The number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. This article presents the results of assessing the antiviral activity of 1,2,3-triazole-containing derivatives of alkaloid lupinine for their ability to suppress the reproduction of orthomyxoviruses (influenza viruses: A/Vladivostok/2/09 (H1N1) and A/Almaty/8/98 (H3N2)). The ability of (1S,9aR)-1-[(1,2,3-triazol-1-yl)-methyl]octahydro-1H-quinolizines with aryl-, 4-((4-formylphenoxy)methyl)- or 4-((3-tert-butyl-5-ethyl-2-hydroxy-benzoyloxy)methyl)- substituents at the C-4 position of the triazole ring to reduce the infectivity of the virus when processing virus-containing material was established, indicating good prospects for the studied compounds as virucidal agents affecting extracellular virions. The experimental results demonstrated that the triazolyl lupinine derivatives exhibited varying degrees of affinity for both hemagglutinin and neuraminidase proteins. Furthermore, these compounds demonstrated inhibitory effects on the replication of influenza viruses with different antigenic subtypes. The obtained biological data are in agreement with the results of molecular docking, which showed strong binding energies of the investigated compounds under study with biological targets—hemagglutinin and neuraminidase proteins. Following the evaluation of antiviral efficacy among the studied triazolyl derivatives of lupinine, four compounds have been identified for subsequent comprehensive in vitro and in vivo investigations to further elucidate their antiviral properties
Текстовый файл
Baskı/Yayın Bilgisi: 2024
Konular:
alkaloid lupinine
(1S,9aR)-1-[(1,2,3-triazol-1-yl)methyl]octahydro-1H-quinolizines
antiviral activity
orthomyxoviruses
rimantadine
Tamiflu
molecular docking
электронный ресурс
труды учёных ТПУ
Online Erişim:https://doi.org/10.3390/molecules29235742
Materyal Türü: Elektronik Kitap Bölümü
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=678076

Benzer Materyaller

Benzer Materyaller