Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine; Molecules; Vol. 29, iss. 15

Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine

Bibliografiska uppgifter
Parent link:Molecules.— .— Basel: MDPI AG
Vol. 29, iss. 15.— 2024.— Article number 3606, 14 p.
Övriga upphovsmän: Nurkenov O. A. Oralgazy, Zhautikova S. B. Saule, Khlebnikov A. I. Andrey Ivanovich, Syzdykov A. K. Ardak, Fazylov S. D. Serik, Seilkhanov T. M. Tulegen, Kabieva S. K. Saule, Turdybekov K. M. Kobylandy, Mendibayeva A. Z. Anel, Zhumanazarova G. M. Gaziza
Sammanfattning:Title screen
The data on the synthesis of N-aminomorpholine hydrazones are presented. It is shown that the interaction of N-aminomorpholine with functionally substituted benzaldehydes and 4-pyridinaldehyde in isopropyl alcohol leads to the formation of corresponding hydrazones. The structure of the synthesized compounds was studied by 1H and 13C NMR spectroscopy methods, including the COSY (1H-1H), HMQC (1H-13C) and HMBC (1H-13C) methodologies. The values of chemical shifts, multiplicity, and integral intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. The COSY (1H-1H), HMQC (1H-13C), and HMBC (1H-13C) results revealed homo- and heteronuclear interactions, confirming the structure of the studied compounds. The antiviral, cytotoxic, and antimicrobial activity of some synthesized hydrazones were investigated. It is shown that 2-((morpholinoimino)methyl)benzoic acid has a pronounced viral inhibitory property, comparable in its activity to commercial drugs Tamiflu and Remantadine. A docking study was performed using the influenza virus protein models (1930 Swine H1 Hemagglutinin and Neuraminidase of 1918 H1N1 strain). The potential binding sites that are complementary with 2-((morpholinoimino)methyl)benzoic acid were found
Текстовый файл
Språk:engelska
Publicerad: 2024
Ämnen:
N-aminomorpholine
hydrazones
functionally substituted benzaldehydes
o-formyl benzoic acid
3-acetoxy-isoindolin-1-ones
NMR spectroscopy
antiviral activity
molecular modeling
электронный ресурс
труды учёных ТПУ
Länkar:https://doi.org/10.3390/molecules29153606
Materialtyp: Elektronisk Bokavsnitt
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=678075

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