Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine
| Parent link: | Molecules.— .— Basel: MDPI AG Vol. 29, iss. 15.— 2024.— Article number 3606, 14 p. |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , |
| الملخص: | Title screen The data on the synthesis of N-aminomorpholine hydrazones are presented. It is shown that the interaction of N-aminomorpholine with functionally substituted benzaldehydes and 4-pyridinaldehyde in isopropyl alcohol leads to the formation of corresponding hydrazones. The structure of the synthesized compounds was studied by 1H and 13C NMR spectroscopy methods, including the COSY (1H-1H), HMQC (1H-13C) and HMBC (1H-13C) methodologies. The values of chemical shifts, multiplicity, and integral intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. The COSY (1H-1H), HMQC (1H-13C), and HMBC (1H-13C) results revealed homo- and heteronuclear interactions, confirming the structure of the studied compounds. The antiviral, cytotoxic, and antimicrobial activity of some synthesized hydrazones were investigated. It is shown that 2-((morpholinoimino)methyl)benzoic acid has a pronounced viral inhibitory property, comparable in its activity to commercial drugs Tamiflu and Remantadine. A docking study was performed using the influenza virus protein models (1930 Swine H1 Hemagglutinin and Neuraminidase of 1918 H1N1 strain). The potential binding sites that are complementary with 2-((morpholinoimino)methyl)benzoic acid were found Текстовый файл |
| اللغة: | الإنجليزية |
| منشور في: |
2024
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.3390/molecules29153606 |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=678075 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 678075 | ||
| 005 | 20250111181548.0 | ||
| 090 | |a 678075 | ||
| 100 | |a 20250111d2024 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a CH | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i |b e | |
| 182 | 0 | |a b | |
| 183 | 0 | |a cr |2 RDAcarrier | |
| 200 | 1 | |a Synthesis and Biological Activity of New Hydrazones Based on N-Aminomorpholine |f Oralgazy A. Nurkenov, Saule B. Zhautikova, Andrei I. Khlebnikov [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 43 tit | ||
| 330 | |a The data on the synthesis of N-aminomorpholine hydrazones are presented. It is shown that the interaction of N-aminomorpholine with functionally substituted benzaldehydes and 4-pyridinaldehyde in isopropyl alcohol leads to the formation of corresponding hydrazones. The structure of the synthesized compounds was studied by 1H and 13C NMR spectroscopy methods, including the COSY (1H-1H), HMQC (1H-13C) and HMBC (1H-13C) methodologies. The values of chemical shifts, multiplicity, and integral intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. The COSY (1H-1H), HMQC (1H-13C), and HMBC (1H-13C) results revealed homo- and heteronuclear interactions, confirming the structure of the studied compounds. The antiviral, cytotoxic, and antimicrobial activity of some synthesized hydrazones were investigated. It is shown that 2-((morpholinoimino)methyl)benzoic acid has a pronounced viral inhibitory property, comparable in its activity to commercial drugs Tamiflu and Remantadine. A docking study was performed using the influenza virus protein models (1930 Swine H1 Hemagglutinin and Neuraminidase of 1918 H1N1 strain). The potential binding sites that are complementary with 2-((morpholinoimino)methyl)benzoic acid were found | ||
| 336 | |a Текстовый файл | ||
| 461 | 1 | |t Molecules |c Basel |n MDPI AG | |
| 463 | 1 | |t Vol. 29, iss. 15 |v Article number 3606, 14 p. |d 2024 | |
| 610 | 1 | |a N-aminomorpholine | |
| 610 | 1 | |a hydrazones | |
| 610 | 1 | |a functionally substituted benzaldehydes | |
| 610 | 1 | |a o-formyl benzoic acid | |
| 610 | 1 | |a 3-acetoxy-isoindolin-1-ones | |
| 610 | 1 | |a NMR spectroscopy | |
| 610 | 1 | |a antiviral activity | |
| 610 | 1 | |a molecular modeling | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Nurkenov |b O. A. |g Oralgazy | |
| 701 | 1 | |a Zhautikova |b S. B. |g Saule | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |9 17500 | |
| 701 | 1 | |a Syzdykov |b A. K. |g Ardak | |
| 701 | 1 | |a Fazylov |b S. D. |g Serik | |
| 701 | 1 | |a Seilkhanov |b T. M. |g Tulegen | |
| 701 | 1 | |a Kabieva |b S. K. |g Saule | |
| 701 | 1 | |a Turdybekov |b K. M. |g Kobylandy | |
| 701 | 1 | |a Mendibayeva |b A. Z. |g Anel | |
| 701 | 1 | |a Zhumanazarova |b G. M. |g Gaziza | |
| 801 | 0 | |a RU |b 63413507 |c 20250111 | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.3390/molecules29153606 |z https://doi.org/10.3390/molecules29153606 | |
| 942 | |c CF | ||