Phytochemical Composition and Biological Activity of the Essential Oil from Ericameria nauseosa Collected in Southwestern Montana, United States; Plants; Vol. 13, iss. 15

Phytochemical Composition and Biological Activity of the Essential Oil from Ericameria nauseosa Collected in Southwestern Montana, United States; Plants; Vol. 13, iss. 15

Bibliographische Detailangaben
Parent link:Plants.— .— Basel: MDPI AG
Vol. 13, iss. 15.— 2024.— Article number 2063, 15 p.
Körperschaft: National Research Tomsk Polytechnic University (570)
Weitere Verfasser: Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Özek G. Gulmira, Özek T. Temel, Kirpotina L. N. Liliya Nikolaevna, Khlebnikov A. I. Andrey Ivanovich, Ayçiçek K. Kevser, Lavin M. Matthew, Quinn M. T. Mark
Zusammenfassung:Title screen
Ericameria nauseosa (Pall. ex Pursh) G.L. Nesom & G.I. Baird) is used in traditional medicine to treat various diseases; however, little is known about the immunomodulatory activity of essential oil from this plant. Thus, we isolated essential oil from the aerial parts of E. nauseosa and evaluated their chemical composition and biological activity. Compositional analysis of E. nauseosa essential oil revealed that the main (>2%) components were γ-decalactone (13.3%), cryptone (9.4%), terpinen-4-ol (9.3%), (E)-methyl cinnamate (6.0%), T-cadinol (4.7%), spathulenol (3.6%), 8Z-2,3-dihydromatricaria ester (3.1%), β-phellandrene (3.0%), p-cymen-8-ol (2.2%), 3-ethoxy-2-cycloocten-1-one (2.2%), and trans-p-menth-2-en-1-ol (2.1%). Distinctive features were the lactones (up to 15%) and polyacetylenes (up to 3.1%), including (2Z,8Z)-matricaria ester and 8Z-2,3-dihydromatricaria ester. A comparison with other reported E. nauseosa essential oil samples showed that our samples were distinct from those collected in other areas of the country; however, they did have the most similarity to one sample collected in North Central Utah. Pharmacological studies showed that E. nauseosa essential oil activated human neutrophil Ca2+ influx, which desensitized these cells to subsequent agonist-induced functional responses. Based on our previously reported data that nerolidol, β-pinene, spathulenol, sabinene, and γ-terpinene were active in human neutrophils, these compounds are the most likely constituents contributing to this immunomodulatory activity. However, the relatively high amount of polyacetylenes may also contribute, as these compounds have been characterized as potent immunomodulators
Текстовый файл
Sprache:Englisch
Veröffentlicht: 2024
Schlagworte:
neutrophil
calcium influx
chemotaxis
immunomodulatory activity
cluster analysis
principal component analysis
электронный ресурс
труды учёных ТПУ
Online-Zugang:https://doi.org/10.3390/plants13152063
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=678074

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