Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy; Molecules; Vol. 29, iss. 16

Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy

Bibliografiske detaljer
Parent link:	Molecules.— .— Basel: MDPI AG Vol. 29, iss. 16.— 2024.— Article number 3820, 11 p.
Institution som forfatter:	National Research Tomsk Polytechnic University (570)
Andre forfattere:	Andrianov V. V., Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Bazan L. V., Gainutdinov K. L., Kovrizhina A. R. Anastasia Ruslanovna, Atochin D. N. Dmitry Nikolaevich, Khlebnikov A. I. Andrey Ivanovich
Summary:	Title screen IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) is a specific c-Jun N-terminal kinase (JNK) inhibitor with anticancer and neuro- and cardioprotective properties. Because aryloxime derivatives undergo cytochrome P450-catalyzed oxidation to nitric oxide (NO) and ketones in liver microsomes, NO formation may be an additional mechanism of IQ-1 pharmacological action. In the present study, electron paramagnetic resonance (EPR) of the Fe2+ complex with diethyldithiocarbamate (DETC) as a spin trap and hemoglobin (Hb) was used to detect NO formation from IQ-1 in the liver and blood of rats, respectively, after IQ-1 intraperitoneal administration (50 mg/kg). Introducing the spin trap and IQ-1 led to signal characteristics of the complex (DETC)2-Fe2+-NO in rat liver. Similarly, the introduction of the spin trap components and IQ-1 resulted in an increase in the Hb-NO signal for both the R- and the T-conformers in blood samples. The density functional theory (DFT) calculations were in accordance with the experimental data and indicated that the NO formation of IQ-1 through the action of superoxide anion radical is thermodynamically favorable. We conclude that the administration of IQ-1 releases NO during its oxidoreductive bioconversion in vivo Текстовый файл
Sprog:	engelsk
Udgivet:	2024
Fag:	электронный ресурс труды учёных ТПУ c-Jun N-terminal kinase (JNK) inhibitor IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) electron paramagnetic resonance nitric oxide donor spin trap hemoglobin DFT calculation
Online adgang:	https://doi.org/10.3390/molecules29163820
Format:	Electronisk Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675620

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