Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats; Bulletin of Experimental Biology and Medicine; Vol. 177, iss. 3

Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats

Bibliografiset tiedot
Parent link:Bulletin of Experimental Biology and Medicine=Бюллетень экспериментальной биологии и медицины.— .— New York: Springer Science+Business Media LLC.
Vol. 177, iss. 3.— 2024.— P. 344–348
Yhteisötekijä: National Research Tomsk Polytechnic University (570)
Muut tekijät: Chernysheva, Smol’iakova V. I. Vera Ivanovna, Plotnikov M. B., Ulyakhina O. A., Osipenko A. N. Anton Nikolaevich, Kovrizhina A. R. Anastasia Ruslanovna, Khlebnikov A. I. Andrey Ivanovich
Yhteenveto:Title screen
The neuroprotective activity of tryptanthrin and its oxime was compared in male Wistar rats with a model of intraluminal occlusion of the middle cerebral artery. Neurobehavioral tests were performed 4, 24, and 48 h after focal cerebral infarction (FCI) using a modified neurological severity score (mNSS); additionally, the horizontal stability test, the plantar sensitivity test of the fore and hind limbs, holding on the tilted cage top test, and negative geotaxis test were performed. The size of FCI and the severity of brain tissue swelling were examined on day 2 after occlusion. Tryptanthrin and its oxime were administered at a dose of 10 mg/kg intraperitoneally during FCI, then daily for 2 days. In the control group, the mean score of neurological deficit remained at a high level for 2 days. FCI size was 43.8±3.4% of hemisphere area, and the hemisphere volume increased by 18.5±2.0% due to brain tissue swelling and edema. Administration of tryptanthrin and its oxime significantly decreased neurological deficits at all control points and reduced FCI size (by 24.2 and 30.4%, respectively) and brain tissue swelling of the affected hemisphere (by 64.9 and 62.7%, respectively). Therefore, the neuroprotective effect of tryptanthrine and its oxime in the acute period of FCI is largely determined by their anti-inflammatory activity
Текстовый файл
AM_Agreement
Kieli:englanti
Julkaistu: 2024
Aiheet:
электронный ресурс
труды учёных ТПУ
brain infarction
neuroprotection
tryptanthrin
tryptanthrin oxime
rats
Linkit:https://doi.org/10.1007/s10517-024-06186-w
Статья на русском языке
Aineistotyyppi: Elektroninen Kirjan osa
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675573

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