Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats; Bulletin of Experimental Biology and Medicine; Vol. 177, iss. 3
| Parent link: | Bulletin of Experimental Biology and Medicine=Бюллетень экспериментальной биологии и медицины.— .— New York: Springer Science+Business Media LLC. Vol. 177, iss. 3.— 2024.— P. 344–348 |
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| مؤلف مشترك: | |
| مؤلفون آخرون: | , , , , , , |
| الملخص: | Title screen The neuroprotective activity of tryptanthrin and its oxime was compared in male Wistar rats with a model of intraluminal occlusion of the middle cerebral artery. Neurobehavioral tests were performed 4, 24, and 48 h after focal cerebral infarction (FCI) using a modified neurological severity score (mNSS); additionally, the horizontal stability test, the plantar sensitivity test of the fore and hind limbs, holding on the tilted cage top test, and negative geotaxis test were performed. The size of FCI and the severity of brain tissue swelling were examined on day 2 after occlusion. Tryptanthrin and its oxime were administered at a dose of 10 mg/kg intraperitoneally during FCI, then daily for 2 days. In the control group, the mean score of neurological deficit remained at a high level for 2 days. FCI size was 43.8±3.4% of hemisphere area, and the hemisphere volume increased by 18.5±2.0% due to brain tissue swelling and edema. Administration of tryptanthrin and its oxime significantly decreased neurological deficits at all control points and reduced FCI size (by 24.2 and 30.4%, respectively) and brain tissue swelling of the affected hemisphere (by 64.9 and 62.7%, respectively). Therefore, the neuroprotective effect of tryptanthrine and its oxime in the acute period of FCI is largely determined by their anti-inflammatory activity Текстовый файл AM_Agreement |
| اللغة: | الإنجليزية |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1007/s10517-024-06186-w Статья на русском языке |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675573 |
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| 200 | 1 | |a Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats |f G. A. Chernysheva, V. I. Smolyakova, M. B. Plotnikov [et al.] |d Сравнительная оценка нейропротекторной активности триптантрина и его оксима при окклюзии средней мозговой артерии у крыс |z rus | |
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| 330 | |a The neuroprotective activity of tryptanthrin and its oxime was compared in male Wistar rats with a model of intraluminal occlusion of the middle cerebral artery. Neurobehavioral tests were performed 4, 24, and 48 h after focal cerebral infarction (FCI) using a modified neurological severity score (mNSS); additionally, the horizontal stability test, the plantar sensitivity test of the fore and hind limbs, holding on the tilted cage top test, and negative geotaxis test were performed. The size of FCI and the severity of brain tissue swelling were examined on day 2 after occlusion. Tryptanthrin and its oxime were administered at a dose of 10 mg/kg intraperitoneally during FCI, then daily for 2 days. In the control group, the mean score of neurological deficit remained at a high level for 2 days. FCI size was 43.8±3.4% of hemisphere area, and the hemisphere volume increased by 18.5±2.0% due to brain tissue swelling and edema. Administration of tryptanthrin and its oxime significantly decreased neurological deficits at all control points and reduced FCI size (by 24.2 and 30.4%, respectively) and brain tissue swelling of the affected hemisphere (by 64.9 and 62.7%, respectively). Therefore, the neuroprotective effect of tryptanthrine and its oxime in the acute period of FCI is largely determined by their anti-inflammatory activity | ||
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| 461 | 1 | |t Bulletin of Experimental Biology and Medicine |c New York |n Springer Science+Business Media LLC. |l Бюллетень экспериментальной биологии и медицины | |
| 463 | 1 | |t Vol. 177, iss. 3 |v P. 344–348 |d 2024 | |
| 610 | 1 | |a электронный ресурс | |
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| 610 | 1 | |a brain infarction | |
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| 610 | 1 | |a tryptanthrin | |
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