The Influence of Silver-Containing Bionanomaterials Based on Humic Ligands on Biofilm Formation in Opportunistic Pathogens

The Influence of Silver-Containing Bionanomaterials Based on Humic Ligands on Biofilm Formation in Opportunistic Pathogens

Detalles Bibliográficos
Parent link:Nanomaterials.— .— Basel: MDPI AG
Vol. 14, iss. 17.— 2024.— Article number 1453, 29 p.
Autor Corporativo: National Research Tomsk Polytechnic University (570)
Otros Autores: Zykova M. V. Mariya Vladimirovna, Karpova M. R. Mariya Rostislavovna, Chzhan Yuy, Chubik M. V. Marianna Valerianovna, Shunkova D. M. Daria, Azarkina L. A. Lyudmila, Mikhalev D. A. Dmitry Aleksandrovich, Konstantinov A. I. Andrey, Plotnikov E. V. Evgeny Vladimirovich, Pestryakov A. N. Aleksey Nikolaevich, Perminova I. V. Irina Vasiljevna, Belousov M. V. Mikhail Valerjevich
Sumario:Title screen
The uncontrolled use of antibiotics has led to a global problem of antimicrobial resistance. One of the main mechanisms of bacterial resistance is the formation of biofilms. In order to prevent the growth of antimicrobial resistance, it is crucial to develop new antibacterial agents that are capable of inhibiting the formation of biofilms. This makes this area of research highly relevant today. Promising candidates for these antibacterial agents are new bionanomaterials made from natural humic substances and silver nanoparticles. These substances have the potential to not only directly kill microorganisms but also penetrate biofilms and inhibit their formation. The goal of this study is to synthesize active pharmaceutical substances in the form of bionanomaterials, using ultradispersed silver nanoparticles in a matrix of coal humic substances, perform their characterization (NMR spectroscopy, TEM, and ICP-AES methods), and research their influence on biofilm formation in the most dangerous opportunistic pathogens (E. coli, Methicillin-resistant St. Aureus, K. pneumoniae, P. aeruginosa, St. aureus, A. baumannii, and K. Pneumonia). The results showed that all of the studied bionanomaterials had antibacterial activity against all of the opportunistic pathogens. Furthermore, they were found to have a suppressive effect on both pre-existing biofilms of these bacteria and their formation
Текстовый файл
Lenguaje:inglés
Publicado: 2024
Materias:
электронный ресурс
труды учёных ТПУ
humic substances
phenol–humic derivatives
silver nanoparticles
opportunistic pathogens
antibacterial activity
biofilm formation
Acceso en línea:http://earchive.tpu.ru/handle/11683/132459
https://doi.org/10.3390/nano14171453
Formato: Electrónico Capítulo de libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675326

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