Оксим инденохиноксалинона IQ-1 как перспективный агент для разработки лекарственных препаратов; Перспективы развития фундаментальных наук; Т. 2 : Химия

Оксим инденохиноксалинона IQ-1 как перспективный агент для разработки лекарственных препаратов; Перспективы развития фундаментальных наук; Т. 2 : Химия

Bibliografische gegevens
Parent link:	Курзина, И. А. (химик ; 1972-). Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XXI Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 23-26 апреля 2024 г..— .— Томск: Изд-во ТПУ Т. 2 : Химия.— 2024.— С. 116-118
Hoofdauteur:	Коврижина А. Р. Анастасия Руслановна
Coauteur:	Томский политехнический университет (570)
Andere auteurs:	Лесина Ю. А. Юлия Александровна (научный руководитель), Андрианов В. В., Хлебников А. И. Андрей Иванович
Samenvatting:	Заглавие с экрана In the present study, we synthesized and investigated the 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) as a promising pharmacological substance with anti-ischemic, antihypertensive, and hypolipidemic properties. An experimental study of nitric oxide (NO) formation in vivo was undertaken with the use of EPR methodology. A mechanism for the NO release by the enzymatic oxidation of IQ-1 was proposed. We have developed a technological scheme for the IQ-1 synthesis based on low-cost starting materials Текстовый файл
Taal:	Russisch
Gepubliceerd in:	2024
Onderwerpen:	труды учёных ТПУ электронный ресурс pharmaceutical substance IQ-1 NO-donor JNK inhibitor hypolipidemic activity
Online toegang:	http://earchive.tpu.ru/handle/11683/80590
Formaat:	Elektronisch Hoofdstuk
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=674025

Gelijkaardige items

Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy; Molecules; Vol. 29, iss. 16
Gepubliceerd in: (2024)

Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S); Cells; Vol. 14, iss. 12
Gepubliceerd in: (2025)

JNK Signaling Pathway Activity Alterations in the Rat Hippocampus: Effect of Age, Alzheimer’s Disease-Like Pathology Development, and the JNK Inhibitor IQ-1S; Biochemistry (Moscow); Vol. 90, iss. 2
Gepubliceerd in: (2025)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats; Molecules; Vol. 24, iss. 9
Gepubliceerd in: (2019)

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors; Molecules; Vol. 30, iss. 11
Gepubliceerd in: (2025)

Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S; Biomedicines; Vol. 11, iss. 2
Gepubliceerd in: (2023)

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells; European Journal of Pharmacology; Vol. 878
Gepubliceerd in: (2020)

The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain; Neurochemical Journal; Vol. 17, iss. 3
Gepubliceerd in: (2023)

Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats; Hypertension Research; Vol. 43
Gepubliceerd in: (2020)

c-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury; Neuroscience and Behavioral Physiology; Vol. 48, iss. 6
Gepubliceerd in: (2019)

Poly(ε-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation; ACS Biomaterials Science and Engineering; Vol. 5, iss. 11
Gepubliceerd in: (2019)

Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats; Bulletin of Experimental Biology and Medicine; Vol. 175, iss. 6
Gepubliceerd in: (2023)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury; Frontiers in Pharmacology; Vol. 9
Gepubliceerd in: (2018)

Target Identification and Validation in Drug Discovery Methods and Protocols /
Gepubliceerd in: (2019)

Animal Cell Biotechnology Methods and Protocols /
Gepubliceerd in: (2020)

Nanoparticles in Biology and Medicine Methods and Protocols /
Gepubliceerd in: (2020)

TRP Channels Methods and Protocols /
Gepubliceerd in: (2019)

Pharmaceutical Nanotechnology Basic Protocols /
Gepubliceerd in: (2019)

Bioinformatics and Drug Discovery
Gepubliceerd in: (2019)

Targeted Protein Degradation Methods and Protocols /
Gepubliceerd in: (2021)

Enzyme Kinetics in Drug Metabolism Fundamentals and Applications /
Gepubliceerd in: (2021)

Effect of Na+,K+,2Cl- Cotransport Inhibitor Bumetanide on Electrical and Contractile Activity of Smooth Muscle Cells in Guinea Pig Ureter; Bulletin of Experimental Biology and Medicine; Vol. 136, iss. 2
Gepubliceerd in: (2003)

Monoamine Oxidase Methods and Protocols /
Gepubliceerd in: (2023)

Cytochrome P450 In Vitro Methods and Protocols /
Gepubliceerd in: (2021)

Computer-Aided Antibody Design
Gepubliceerd in: (2023)

Современные подходы в градостроительной деятельности. «Умный» устойчивый город учебно-методическое пособие
door: Бакаева Н. В.
Gepubliceerd in: (Москва, МИСИ – МГСУ, 2022)

Daily Routine in Cosmetic Dermatology
Gepubliceerd in: (2016)

Lasers, Lights and Other Technologies
Gepubliceerd in: (2016)

Chemical and Physical Procedures
Gepubliceerd in: (2016)

Botulinum Toxins, Fillers and Related Substances
Gepubliceerd in: (2016)

Specific features of epithelium-dependent contractile reactions of smooth muscles in various subdivisions of the respiratory tract; Bulletin of Experimental Biology and Medicine; Vol. 126, iss. 6
Gepubliceerd in: (1998)

Cyclic Peptide Design
Gepubliceerd in: (2019)

Engineering Natural Product Biosynthesis Methods and Protocols /
Gepubliceerd in: (2022)

Immuno-Oncology Cellular and Translational Approaches /
Gepubliceerd in: (2020)

Quantum Mechanics in Drug Discovery
Gepubliceerd in: (2020)

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Gepubliceerd in: (2022)

Targeting Enzymes for Pharmaceutical Development Methods and Protocols /
Gepubliceerd in: (2020)

Basic Techniques in Biochemistry, Microbiology and Molecular Biology Principles and Techniques /
door: Jain, Aakanchha, et al.
Gepubliceerd in: (2020)

Chiral Separations Methods and Protocols /
Gepubliceerd in: (2019)

Peptide Synthesis Methods and Protocols /
Gepubliceerd in: (2020)