Оксим инденохиноксалинона IQ-1 как перспективный агент для разработки лекарственных препаратов
| Parent link: | Курзина, И. А. (химик ; 1972-). Перспективы развития фундаментальных наук=Prospects of Fundamental Sciences Development: сборник научных трудов XXI Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 23-26 апреля 2024 г..— .— Томск: Изд-во ТПУ Т. 2 : Химия.— 2024.— С. 116-118 |
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| Summary: | Заглавие с экрана In the present study, we synthesized and investigated the 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) as a promising pharmacological substance with anti-ischemic, antihypertensive, and hypolipidemic properties. An experimental study of nitric oxide (NO) formation in vivo was undertaken with the use of EPR methodology. A mechanism for the NO release by the enzymatic oxidation of IQ-1 was proposed. We have developed a technological scheme for the IQ-1 synthesis based on low-cost starting materials Текстовый файл |
| Language: | Russian |
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2024
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| Online Access: | http://earchive.tpu.ru/handle/11683/80590 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=674025 |
| Summary: | Заглавие с экрана In the present study, we synthesized and investigated the 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) as a promising pharmacological substance with anti-ischemic, antihypertensive, and hypolipidemic properties. An experimental study of nitric oxide (NO) formation in vivo was undertaken with the use of EPR methodology. A mechanism for the NO release by the enzymatic oxidation of IQ-1 was proposed. We have developed a technological scheme for the IQ-1 synthesis based on low-cost starting materials Текстовый файл |
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