Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level

Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level

Bibliographic Details
Parent link:Nano Today.— .— Amsterdam: Elsevier Science Publishing Company Inc.
Vol. 56.— 2024.— Article number 102300, 14 p.
Corporate Author: National Research Tomsk Polytechnic University (570)
Other Authors: Pershina A. G. Aleksandra Gennadievna, Efimova L. V. Lina Viktorovna, Brikunova O. Ya. Olga Yaroslavovna, Nevskaya K. V. Ksenia Vladimirovna, Sukhinina E. V. Ekaterina Vladimirovna, Hmelevskaya E. S. Ekaterina Sergeevna, Demin A. M. Aleksandr Mikhaylovich, Naumenko Viktor Alekseevich, Malkeeva D. Dina, Kiseleva E. Elena, Khozyainova A. A. Anna, Menyaylo M. E. Maksim Evgenjevich, Denisov E. V. Evgeny Vladimirovich, Volegov A. S. Aleksey, Uymin M. A. Mikhail Aleksandrovich
Summary:Title screen
A benefit of biomedical application of nanosystems is implementation of a precise effect at the level of an individual cell, and magnetic nanoparticles (MNPs) are some of the best candidates for the development of an intelligent nanosystem with remote control. To develop a nanosystem for precise therapy, a deep understanding of the nanosystem’s in vivo behavior is required. Here, we studied penetration and distribution of PEGylated iron oxide MNPs unmodified or modified with the pH low insertion peptide (a ligand for smart targeting of the tumor acidic microenvironment) in vivo in a 4T1 mouse tumor. We revealed that MNPs penetrate into the tumor via both vascular burst and endothelial transcytosis. By implementing an approach based on single-cell high-throughput RNA sequencing, we identified the populations of the cells that took up MNPs in the 4T1 tumor and revealed preferential accumulation of MNPs in regulatory Trem2+ tumor-associated macrophages.
Текстовый файл
AM_Agreement
Published: 2024
Subjects:
электронный ресурс
труды учёных ТПУ
Cancer
Magnetic nanoparticles
Nano-bio interaction
Distribution
Single-cell sequencing
Online Access:https://doi.org/10.1016/j.nantod.2024.102300
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=673572

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