Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review; Materials Today Bio; Vol. 25

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review; Materials Today Bio; Vol. 25

Bibliografische gegevens
Parent link:Materials Today Bio.— .— Amsterdam: Elsevier Science Publishing Company Inc.
Vol. 25.— 2024.— Article number 100950, 31 p.
Coauteur: National Research Tomsk Polytechnic University (570)
Andere auteurs: Shlapakova L. E. Lada Evgenievna, Surmeneva M. A. Maria Alexandrovna, Kholkin A. L. Andrei Leonidovich, Surmenev R. A. Roman Anatolievich
Samenvatting:Title screen
Nerve injuries pose a drastic threat to nerve mobility and sensitivity and lead to permanent dysfunction due to low regenerative capacity of mature neurons. The electrical stimuli that can be provided by electroactive materials are some of the most effective tools for the formation of soft tissues, including nerves. Electric output can provide a distinctly favorable bioelectrical microenvironment, which is especially relevant for the nervous system. Piezoelectric biomaterials have attracted attention in the field of neural tissue engineering owing to their biocompatibility and ability to generate piezoelectric surface charges. In this review, an outlook of the most recent achievements in the field of piezoelectric biomaterials is described with an emphasis on piezoelectric polymers for neural tissue engineering. First, general recommendations for the design of an optimal nerve scaffold are discussed. Then, specific mechanisms determining nerve regeneration via piezoelectric stimulation are considered. Activation of piezoelectric responses via natural body movements, ultrasound, and magnetic fillers is also examined. The use of magnetoelectric materials in combination with alternating magnetic fields is thought to be the most promising due to controllable reproducible cyclic deformations and deep tissue permeation by magnetic fields without tissue heating. In vitro and in vivo applications of nerve guidance scaffolds and conduits made of various piezopolymers are reviewed too. Finally, challenges and prospective research directions regarding piezoelectric biomaterials promoting nerve regeneration are discussed. Thus, the most relevant scientific findings and strategies in neural tissue engineering are described here, and this review may serve as a guideline both for researchers and clinicians
Текстовый файл
AM_Agreement
Taal:Engels
Gepubliceerd in: 2024
Onderwerpen:
электронный ресурс
труды учёных ТПУ
piezoelectric polymer
polyvinylidene fluoride
poly(L-lactic acid)
polyhydroxyalkanoate
nerve guidance conduit
Online toegang:https://doi.org/10.1016/j.mtbio.2024.100950
Formaat: Elektronisch Hoofdstuk
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=673398

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