General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides

General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides

Bibliographische Detailangaben
Parent link:Organic Letters.— .— Washington: ACS Publications
Vol. 26, iss. 16.— 2024.— P. 3380–3385
Körperschaft: National Research Tomsk Polytechnic University
Weitere Verfasser: Qing Yan, Qing-Jia Yuan, Shatskiy A. Andrey, Alvey G. R. Gregory, Stepanova E. V. Elena Vladimirovna, Jian-Quan Liu, Karkas M. D. Markus, Xiang-Shan Wang
Zusammenfassung:Title screen
Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through a free-radical mechanism. The disclosed approach provides a general entry to a variety of decorated amides, accommodating a diverse array of radical precursors, including aryl, heteroaryl, alkynyl, alkenyl, and alkyl carboxylic acids. Notably, the protocol proved to be efficient for decarboxylative late-stage functionalization of several elaborate pharmaceuticals, demonstrating its potential applications.
Текстовый файл
Sprache:Englisch
Veröffentlicht: 2024
Schlagworte:
труды учёных ТПУ
электронный ресурс
Online-Zugang:https://doi.org/10.1021/acs.orglett.4c00872
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672791

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