General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides; Organic Letters; Vol. 26, iss. 16
| Parent link: | Organic Letters.— .— Washington: ACS Publications Vol. 26, iss. 16.— 2024.— P. 3380–3385 |
|---|---|
| Corporate Author: | Томский политехнический университет |
| Other Authors: | Qing Yan, Qing-Jia Yuan, Shatskiy A. Andrey, Alvey G. R. Gregory, Stepanova E. V. Elena Vladimirovna, Jian-Quan Liu, Karkas M. D. Markus, Xiang-Shan Wang |
| Summary: | Title screen Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through a free-radical mechanism. The disclosed approach provides a general entry to a variety of decorated amides, accommodating a diverse array of radical precursors, including aryl, heteroaryl, alkynyl, alkenyl, and alkyl carboxylic acids. Notably, the protocol proved to be efficient for decarboxylative late-stage functionalization of several elaborate pharmaceuticals, demonstrating its potential applications. Текстовый файл |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://doi.org/10.1021/acs.orglett.4c00872 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672791 |
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