Radionuclide Therapy of HER2-Expressing Xenografts Using [177Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab; Cancers; Vol. 15 - iss. 9

Radionuclide Therapy of HER2-Expressing Xenografts Using [177Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab; Cancers; Vol. 15 - iss. 9

Bibliografiske detaljer
Parent link:	Cancers.— .— Basel: MDPI AG Vol. 15 - iss. 9.— 2023.— Article number 2409, P. 1-15
Institution som forfatter:	National Research Tomsk Polytechnic University
Andre forfattere:	Liu Yongsheng, Xu Tianqi, Vorobjeva (Vorobyeva) A. G. Anzhelika Grigorjevna, Loftenius Annika, Bodenko V. V. Vitalina Vasiljevna, Orlova A. M. Anna Markovna, Frejd Y. F. Fredrik, Tolmachev V. M. Vladimir Maksimilianovich
Summary:	ABY-027 is a scaffold-protein-based cancer-targeting agent. ABY-027 includes the secondgeneration Affibody molecule ZHER2:2891, which binds to human epidermal growth factor receptor type 2 (HER2). An engineered albumin-binding domain is fused to ZHER2:2891 to reduce renal uptake and increase bioavailability. The agent can be site-specifically labeled with a beta-emitting radionuclide 177Lu using a DOTA chelator. The goals of this study were to test the hypotheses that a targeted radionuclide therapy using [177Lu]Lu-ABY-027 could extend the survival of mice with HER2-expressing human xenografts and that co-treatment with [177Lu]Lu-ABY-027 and the HER2-targeting antibody trastuzumab could enhance this effect. Balb/C nu/nu mice bearing HER2-expressing SKOV-3 xenografts were used as in vivo models. A pre-injection of trastuzumab did not reduce the uptake of [177Lu]Lu-ABY-027 in tumors. Mice were treated with [177Lu]Lu-ABY-027 or trastuzumab as monotherapies and a combination of these therapies. Mice treated with vehicle or unlabeled ABY-027 were used as controls. Targeted monotherapy using [177Lu]Lu-ABY-027 improved the survival of mice and was more efficient than trastuzumab monotherapy. A combination of therapies utilizing [177Lu]Lu-ABY-027 and trastuzumab improved the treatment outcome in comparison with monotherapies using these agents. In conclusion, [177Lu]Lu-ABY-027 alone or in combination with trastuzumab could be a new potential agent for the treatment of HER2-expressing tumors. Текстовый файл
Sprog:	engelsk
Udgivet:	2023
Fag:	radionuclide therapy Affibody molecule HER2 lutetium-177 труды учёных ТПУ электронный ресурс
Online adgang:	https://doi.org/10.3390/cancers15092409
Format:	Electronisk Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=671222

Lignende værker

Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake; International Journal of Molecular Sciences; Vol. 22, iss. 5
Udgivet: (2021)

Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules; International Journal of Molecular Sciences; Vol. 21, iss. 4
Udgivet: (2020)

Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model; Pharmaceutics; Vol. 12, iss. 6
Udgivet: (2020)

Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion; International Journal of Molecular Sciences; Vol. 25, iss. 8
Udgivet: (2024)

Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules; International Journal of Molecular Sciences; Vol. 21, iss. 6
Udgivet: (2020)

Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs; Journal of Controlled Release; Vol. 355
Udgivet: (2023)

Affibody Molecules as Targeting Vectors for PET Imaging; Cancers; Vol. 12, iss. 3
af: Tolmachev V. M. Vladimir Maksimilianovich
Udgivet: (2020)

Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation; Journal of Controlled Release; Vol. 370
Udgivet: (2024)

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model; Cancers; Vol. 13, iss. 1
Udgivet: (2020)

HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution; Pharmaceutics; Vol. 12, iss. 4
Udgivet: (2020)

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer; EJNMMI Research; Vol. 10, iss. 1
Udgivet: (2020)

Phase I clinical evaluation of 99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer; Theranostics; Vol. 13, iss. 14
Udgivet: (2023)

Технологические аспекты выделения LU-177 из иттербиевой мишени; Изотопы: технологии, материалы и применение
af: Ушаков И. А. Иван Алексеевич
Udgivet: (2023)

Therapy of HER2-expressing human xenografts in mice using 177Lu-labelled scaffold protein ABY-027: compatrison with therapy using antobody trastuzumab; Физико-технические проблемы в науке, промышленности и медицине
af: Liu Y.
Udgivet: (2022)

Разделение нуклидов 177Lu и Yb методом цементации; Изотопы: технологии, материалы и применение
af: Ушаков И. А. Иван Алексеевич
Udgivet: (2021)

Luminescence properties of color tunable new garnet structure (Lu1-xMnx)3Al2(Al1-xSix)3O12: Ce3+ solid solution phosphors; Journal of Luminescence; Vol. 207
Udgivet: (2019)

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3, for Imaging of HER2-Positive Breast Cancer; Cancers; Vol. 15 - iss. 12
Udgivet: (2023)

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3; Nuclear Medicine and Biology; Vol. 124-125
Udgivet: (2023)

HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model; International Journal of Molecular Sciences; Vol. 20, iss. 10
Udgivet: (2019)

Расчет поглощённой дозы в ионообменной смоле при разделении лютеция-177 от иттербия с использованием программного комплекса GEANT4; Изотопы: технологии, материалы и применение
af: Чертков М. С.
Udgivet: (2023)

Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1; Molecules; Vol. 25, iss. 20
Udgivet: (2020)

Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the 99mTc-Based Imaging of HER2-Expressing Malignant Tumors; Molecular Pharmaceutics; Vol. 21, iss. 4
Udgivet: (2024)

Current outlook on radionuclide delivery systems: from design consideration to translation into clinics; Journal of Nanobiotechnology; Vol. 17, iss. 1
Udgivet: (2020)

Особенности получения радионуклида лютеций-177 на реакторе ИРТ-Т; Известия вузов. Физика; Т. 58, № 2/2
Udgivet: (2015)

Особенности получения радионуклида лютеций-177 на реакторе ИРТ-Т; Изотопы: технологии, материалы и применение
af: Зукау В. В. Валерий Викторович
Udgivet: (2014)

Analysis of the Causes of Irregular 36Cl Radionuclide Distribution in Irradiated Nuclear Graphite; Journal of Surface Investigation. X-ray, Synchrotron and Neutron Techniques; Vol. 14, iss. 1
Udgivet: (2020)

Poeme lu au mariage d'Andre Salmon
af: Guillaume A.
Udgivet: (Санкт-Петербург, Лань, 2013)

An investigation of calcium carbonate core-shell particles for incorporation of 225Ac and sequester of daughter radionuclides: in vitro and in vivo studies; Journal of Controlled Release; Vol. 330
Udgivet: (2021)

Calcium Carbonate Core-Shell Particles for Incorporation of 225Ac and Their Application in Local α-Radionuclide Therapy; ACS Applied Materials and Interfaces; Vol. 13, iss. 22
Udgivet: (2021)

Distribution of natural radionuclides in ashes,collected by thermal power plants electrostatic precipitator; Известия Томского политехнического университета [Известия ТПУ]. Инжиниринг георесурсов; Т. 334, № 7
Udgivet: (2023)

Новый уникальный метод точного определения потенциальной функции молекул на основе спектров микроволновых и субмиллиметровых волн: двухатомная молекула; Перспективы развития фундаментальных наук; Т. 1 : Физика
af: Сидько С. С.
Udgivet: (2025)

A Method for the Precise Determination of the Intramolecular Potential Energy Surface on the Basis of Microwave and Submillimeter-Wave Spectra: Diatomic Molecules as a Relevant Illustration; International Journal of Molecular Sciences; Vol. 26, iss. 2
Udgivet: (2025)

Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1; International Journal of Molecular Sciences; Vol. 21, iss. 9
Udgivet: (2020)

Remediation of artificial water basins of uranium enterprises; Методология проектирования молодежного научно-инновационного пространства для российской энергетики
af: Chalov S. A.
Udgivet: (2013)

Comprehensive high resolution study of the SiH tetradecad stretching bands: Appearance and applications of the isotopic substitution effect in molecules of spherical symmetry; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; Vol. 309
Udgivet: (2024)

Влияние расположения ABD на таргетные свойства нового бивалентного терапевтического конъюгата на основе DARPin G3; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
af: Прач А. А. Анастасия Александровна
Udgivet: (2024)

Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape; Cancers; Vol. 12, iss. 10
Udgivet: (2020)

High-Resolution Spectroscopy of the CH2 = CD2 Molecule: Analysis of the Hot ν7 + ν10 - ν10 Band; Russian Physics Journal; Vol. 60, iss. 4
Udgivet: (2017)

Mass Spectrometry Imaging of Small Molecules Methods and Protocols /
Udgivet: (2022)

Determination of Transformation Coefficients of the C2H4 Molecule; Russian Physics Journal; Vol. 59, iss. 7
Udgivet: (2016)