Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study; Biomimetics; Vol. 8, iss. 2

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study; Biomimetics; Vol. 8, iss. 2

Dades bibliogràfiques
Parent link:	Biomimetics Vol. 8, iss. 2.— 2023.— [138, 14 p. ]
Autor corporatiu:	Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Altres autors:	Popkov A. V. Arnold Vasiljevich, Kononovich N. A. Nataljya Andreevna, Dubinenko G. E. Gleb Evgenjevich, Gorbach E. N. Elena Nikolaevna, Shastov A. L. Alexander, Tverdokhlebov S. I. Sergei Ivanovich, Popkov D. A. Dmitry Arnoldovich
Sumari:	Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone regeneration from the periosteum lying on the periphery of cylindrical implant to its center in a week after the surgery. Cellular structure of the implant was fully filled with newly-formed bone tissue on the 4th week after the surgery. The bone tissue regeneration from the proximal and distal bone fragments was evident on 3rd week. This provides insight into the use of bioactive degradable implants for the restoration of segmental bone defects. Degradable implant with bioactive coating implanted into a long bone segmental defect provides stimulation of reparative osteogenesis and osseointegration into the single implant-bone block.
Idioma:	anglès
Publicat:	2023
Matèries:	труды учёных ТПУ электронный ресурс bone defect degradable implant polycaprolactone hydroxyapatite osseointegration
Accés en línia:	https://doi.org/10.3390/biomimetics8020138
Format:	Electrònic Capítol de llibre
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669538

Ítems similars

Hydrolysis of Bone-Replacing Materials Based on Polylactic Acid and Containing Hydroxyapatite in an In Vitro Experiment; Bulletin of Experimental Biology and Medicine; Vol. 174, iss. 1
Publicat: (2022)

Biological activity of the implant for internal fixation; Journal of Tissue Engineering and Regenerative Medicine; Vol. 12, iss. 12
Publicat: (2018)

Immobilization of Hydroxyapatite on the Surface of Porous Piezoelectric Fluoropolymer Implants for the Improved Stem Cell Adhesion and Osteogenic Differentiation; Surfaces; Vol. 9, iss. 1
Publicat: (2026)

First Clinical Case of Ilizarov Femur Lengthening over a Bioactive and Degradable Intramedullary Implant; Case Reports in Orthopedics; Vol. 2023
Publicat: (2023)

Биосовместимость и костная интеграция титановых имплантатов различной пористости с кальций-фосфатным покрытием и без покрытия; Современные технологии в медицине; Т. 13, № 2
Publicat: (2021)

Osteogenic Capability of Vaterite-Coated Nonwoven Polycaprolactone Scaffolds for In Vivo Bone Tissue Regeneration; Macromolecular Bioscience; Vol. 21, iss. 12
Publicat: (2021)

A critical review of decades of research on calcium phosphate–based coatings: How far are we from their widespread clinical application?; Current Opinion in Biomedical Engineering; Vol. 10
per: Surmenev R. A. Roman Anatolievich
Publicat: (2019)

Integration of Graphene into Calcium Phosphate Coating for Implant Electronics; ACS Applied Materials and Interfaces; Vol. 17, iss. 9
Publicat: (2025)

Characterization of biomimetic silicate- and strontium-containing hydroxyapatite microparticles embedded in biodegradable electrospun polycaprolactone scaffolds for bone regeneration; European Polymer Journal; Vol. 113
Publicat: (2019)

Radiation-Induced Degradation of LiF:W-Based Scintillators; Technical Physics Letters; Vol. 45, iss. 7
per: Ge Guanghui (Guang Hui Ge)
Publicat: (2019)

Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment; Symmetry; Vol. 15, iss. 1
Publicat: (2023)

RF magnetron-sputtered coatings deposited from biphasic calcium phosphate targets for biomedical implant applications; Bioactive Materials; Vol. 2, iss. 3
Publicat: (2017)

Phase and elemental composition of silicon-containing hydroxyapatite-based coatings fabricated by RF-magnetron sputtering for medical implants; Inorganic Materials: Applied Research; Vol. 4, iss. 3
Publicat: (2013)

The experimental study of the kinetics and modes of polymethyl methacrylate thermal degradation in argon flows; Thermochimica Acta; Vol. 736
Publicat: (2024)

Biomimetic Synthesis of Strontium-Containing Apatite and Its Peculiar Properties; Biogenic-Abiogenic Interactions in Natural and Anthropogenic Systems
per: Izmaylov R. R. Rinat Rashidovich
Publicat: (2016)

Pulsed Vacuum Arc Deposition of Nitrogen-Doped Diamond-like Coatings for Long-Term Hydrophilicity of Electrospun Poly(ε-caprolactone) Scaffolds; Membranes; Vol. 12, iss. 11
Publicat: (2022)

Bioactive Surface Engineering of Composite Titanium Implants; Inorganic Materials; Vol. 57, iss. 9
per: Petrovskaya T. S. Tatyana Semyonovna
Publicat: (2021)

Effect of long-term operation on steels of main gas pipeline: Structural and mechanical degradation; Journal of King Saud University - Engineering Sciences; Vol. 30, iss. 4
Publicat: (2018)

Heparin Enriched-WPI Coating on Ti6Al4V Increases Hydrophilicity and Improves Proliferation and Differentiation of Human Bone Marrow Stromal Cells; International Journal of Molecular Sciences; Vol. 23, iss. 10
Publicat: (2022)

Functionalizing Diatomite-Based Micro-Arc Coatings for Orthopedic Implants: Influence of TiO2 Addition; Biomimetics; Vol. 8, iss. 3
Publicat: (2023)

Effect of intense electron and ion irradiation on optical absorption of boron carbide thin films; Radiation Effects and Defects in Solids: Incorporating Plasma Science and Plasma Technology; Vol. 173, iss. 11-12
Publicat: (2018)

Beyond Tissue replacement: The Emerging role of smart implants in healthcare; Materials Today Bio; Vol. 22
Publicat: (2023)

In vitro degradation behaviour of hybrid electrospun scaffolds of polycaprolactone and strontium-containing hydroxyapatite microparticles; Polymer Degradation and Stability; Vol. 167
Publicat: (2019)

Toxicity of silver nanoparticles in mouse bone marrow-derived dendritic cells: Implications for phenotype; Journal of Immunotoxicology; Vol. 16, iss. 1
Publicat: (2019)

Synergetic effect of UiO-66 and plasmonic AgNPs on PET waste support towards degradation of nerve agent simulant; Chemical Engineering Journal; Vol. 431
Publicat: (2022)

Osteogenic Potential and Long-Term Enzymatic Biodegradation of PHB-based Scaffolds with Composite Magnetic Nanofillers in a Magnetic Field; ACS Applied Materials and Interfaces; Vol. 16, iss. 42
Publicat: (2024)

3D-printed biodegradable composite poly(lactic acid)-based scaffolds with a shape memory effect for bone tissue engineering; Advanced Composites and Hybrid Materials; Vol. 8, iss. 1
Publicat: (2025)

Cellular and Molecular Basis of Osteoblastic and Vascular Niches in the Processes of Hematopoiesis and Bone Remodeling (A Short Review of Modern Views); Current Pharmaceutical Design; Vol. 25, iss. 6
Publicat: (2019)

Electrospun polycaprolactone scaffolds loaded with a 1,4-naphthoquinone derivative for anticancer therapy; Materials Letters; Vol. 327
Publicat: (2022)

Piezoelectric 3-D Fibrous Poly(3-hydroxybutyrate)-Based Scaffolds Ultrasound-Mineralized with Calcium Carbonate for Bone Tissue Engineering: Inorganic Phase Formation, Osteoblast Cell Adhesion, and Proliferation; ACS Applied Materials and Interfaces; Vol. 21, iss. 11
Publicat: (2019)

Two-Dimensional Silver-Metalated Graphdiyne Nanosheets for Photocatalytic Degradation of Antibiotics; ACS Applied Materials and Interfaces; Vol. 6, iss. 9
Publicat: (2023)

Evaluation of the Bioactive Properties of the Mineral-Polymer Composite Calcium Phosphates – Polylactide; Glass and Ceramics; Vol. 78, iss. 7-8
per: Petrovskaya T. S. Tatyana Semyonovna
Publicat: (2021)

RF-magnetron sputter deposited hydroxyapatite-based composite & multilayer coatings: A systematic review from mechanical, corrosion, and biological points of view; Ceramics International; Vol. 47, iss. 3
Publicat: (2021)

Mechanical and Rheological Properties of Biodegradable Polycaprolactone/Carbon Nanotube Composites; Russian Physics Journal; Vol. 63, iss. 4
per: Lebedev S. M. Sergey Mikhailovich
Publicat: (2020)

Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review; Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry; Vol. 15, iss. 2
Publicat: (2021)

Phenolic-Enriched Collagen Fibrillar Coatings on Titanium Alloy to Promote Osteogenic Differentiation and Reduce Inflammation; International Journal of Molecular Sciences; Vol. 21, iss. 17
Publicat: (2020)

Degradation of Lithium-Ion Batteries in an Electric Transport Complex; Energies; Vol. 14, iss. 23
Publicat: (2021)

Multiscale design of an additively manufactured Ti–Nb alloy with nanostructured Sr-substituted hydroxyapatite coating for bone tissue engineering; Ceramics International; Vol. 51, iss. 25, pt. C
Publicat: (2025)

Creation and Accumulation of Radiation Defects in Single Crystals of Magnesium Oxide; Research Aims and Methodology
per: Surzhikov A. P. Anatoly Petrovich
Publicat: (Cham, Springer Nature Switzerland AG, 2024)

Thermooxidative Degradation of Composites Based on Epoxy Resin and Metal Nanopowders; Materials Science Forum; Vol. 942 : Modern Problems in Materials Processing, Manufacturing, Testing and Quality Assurance
per: Lipchansky D. S. Dmitry Sergeevich
Publicat: (2019)