Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

التفاصيل البيبلوغرافية
Parent link:Biomimetics
Vol. 8, iss. 2.— 2023.— [138, 14 p. ]
مؤلف مشترك: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
مؤلفون آخرون: Popkov A. V. Arnold Vasiljevich, Kononovich N. A. Nataljya Andreevna, Dubinenko G. E. Gleb Evgenjevich, Gorbach E. N. Elena Nikolaevna, Shastov A. L. Alexander, Tverdokhlebov S. I. Sergei Ivanovich, Popkov D. A. Dmitry Arnoldovich
الملخص:Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone regeneration from the periosteum lying on the periphery of cylindrical implant to its center in a week after the surgery. Cellular structure of the implant was fully filled with newly-formed bone tissue on the 4th week after the surgery. The bone tissue regeneration from the proximal and distal bone fragments was evident on 3rd week. This provides insight into the use of bioactive degradable implants for the restoration of segmental bone defects. Degradable implant with bioactive coating implanted into a long bone segmental defect provides stimulation of reparative osteogenesis and osseointegration into the single implant-bone block.
اللغة:الإنجليزية
منشور في: 2023
الموضوعات:
труды учёных ТПУ
электронный ресурс
bone defect
degradable implant
polycaprolactone
hydroxyapatite
osseointegration
الوصول للمادة أونلاين:https://doi.org/10.3390/biomimetics8020138
التنسيق: الكتروني فصل الكتاب
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669538

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