Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

Bibliographic Details
Parent link:Advanced Healthcare Materials
Vol. 12, iss. 8.— 2022.— [2201726, 18 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Международный научно-исследовательский центр "Пьезо- и магнитоэлектрические материалы"
Other Authors: Chernozem R. V. Roman Viktorovich, Pary (Pariy) I. O. Igor Olegovich, Surmeneva M. A. Maria Alexandrovna, Shvartsman V. V. Vladimir, Planckaert G. Guillaume, Verduijn J. Joost, Ghysels S. Stef, Abalymov A. A., Parakhonskiy B. V. Bogdan, Gracey E. Eric, Goncalves A. Amanda, Mathur S. Sanjay, Ronsse F. Frederik, Depla D., Lupascu D. C. Doru
Summary:Title screen
This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions. There is no effect of the rGO addition up to 1.0 wt% on the rate of enzymatic biodegradation of PHB scaffolds for 30 d. The biodegradation of scaffolds leads to the depolymerization of the amorphous phase, resulting in an increase in the degree of crystallinity. Because of more regular dipole order in the crystalline phase, surface potential of all fibers increases after the biodegradation, with a maximum (361 ± 5 mV) after the addition of 1 wt% rGO into PHB as compared to pristine PHB fibers. By contrast, PHB-0.7rGO fibers manifest the strongest effective vertical (0.59 ± 0.03 pm V?1) and lateral (1.06 ± 0.02 pm V?1) piezoresponse owing to a greater presence of electroactive ?-phase. In vitro assays involving primary human fibroblasts reveal equal biocompatibility and faster cell proliferation on PHB-0.7rGO scaffolds compared to pure PHB and nonpiezoelectric polycaprolactone scaffolds. Thus, the developed biodegradable PHB-rGO scaffolds with enhanced piezoresponse are promising for tissue-engineering applications.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2022
Subjects:
электронный ресурс
труды учёных ТПУ
исследования
матриксы
оксид графена
биодеградация
Online Access:https://doi.org/10.1002/adhm.202201726
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669366

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