Ligand-free Ullmann-type arylation of oxazolidinones by diaryliodonium salts
| Parent link: | Organic and Biomolecular Chemistry Vol. 21, iss, 9.— 2023.— [P. 1952-1957] |
|---|---|
| Other Authors: | , , , , , , , |
| Summary: | Title screen The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts – symmetric and unsymmetric as well as ortho-substituted derivatives. The developed approach will provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://doi.org/10.1039/D2OB02122F |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669357 |
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| 200 | 1 | |a Ligand-free Ullmann-type arylation of oxazolidinones by diaryliodonium salts |f E. V. Podrezova, A. A. Okhina, A. D. Rogachev [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 330 | |a The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts – symmetric and unsymmetric as well as ortho-substituted derivatives. The developed approach will provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Organic and Biomolecular Chemistry | ||
| 463 | |t Vol. 21, iss, 9 |v [P. 1952-1957] |d 2023 | ||
| 610 | 1 | |a электронный ресурс | |
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| 701 | 1 | |a Podrezova |b E. V. |c Chemist |c Engineer of Tomsk Polytechnic University |f 1992- |g Ekaterina Vladimirovna |y Tomsk |3 (RuTPU)RU\TPU\pers\40301 |9 21290 | |
| 701 | 1 | |a Okhina |b A. A. |g Alina Aleksandrovna | |
| 701 | 1 | |a Rogachev |b A. D. |g Artem Dmitrievich | |
| 701 | 1 | |a Baykov |b S. V. |c chemist |c Researcher at Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1987- |g Sergey Valentinovich |3 (RuTPU)RU\TPU\pers\47276 |9 22856 | |
| 701 | 1 | |a Kirschning |b A. |g Andreas | |
| 701 | 1 | |a Yusubov |b M. S. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1961- |g Mekhman Suleiman-Ogly (Suleimanovich) |3 (RuTPU)RU\TPU\pers\31833 |9 15928 | |
| 701 | 1 | |a Soldatova |b N. S. |c organic chemist |c engineer of Tomsk Polytechnic University |f 1992- |g Nataliya Sergeevna |3 (RuTPU)RU\TPU\pers\36289 |9 19363 | |
| 701 | 1 | |a Postnikov |b P. S. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1984- |g Pavel Sergeevich |3 (RuTPU)RU\TPU\pers\31287 |9 15465 | |
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