Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium
| Parent link: | Pharmaceutics Vol. 15, iss. 3.— 2023.— [939, 22 p.] |
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| 団体著者: | |
| その他の著者: | , , , , , , , , , , , |
| 要約: | Title screen Biocompatible poly(lactide-co-glycolide) scaffolds fabricated via electrospinning are having promising properties as implants for the regeneration of fast-growing tissues, which are able to degrade in the body. The hereby-presented research work investigates the surface modification of these scaffolds in order to improve antibacterial properties of this type of scaffolds, as it can increase their application possibilities in medicine. Therefore, the scaffolds were surface-modified by means of pulsed direct current magnetron co-sputtering of copper and titanium targets in an inert atmosphere of argon. In order to obtain different amounts of copper and titanium in the resulting coatings, three different surface-modified scaffold samples were produced by changing the magnetron sputtering process parameters. The success of the antibacterial properties’ improvement was tested with the methicillin-resistant bacterium Staphylococcus aureus. In addition, the resulting cell toxicity of the surface modification by copper and titanium was examined using mouse embryonic and human gingival fibroblasts. As a result, the scaffold samples surface-modified with the highest copper to titanium ratio show the best antibacterial properties and no toxicity against mouse fibroblasts, but have a toxic effect to human gingival fibroblasts. The scaffold samples with the lowest copper to titanium ratio display no antibacterial effect and toxicity. The optimal poly(lactide-co-glycolide) scaffold sample is surface-modified with a medium ratio of copper and titanium that has antibacterial properties and is non-toxic to both cell cultures. |
| 言語: | 英語 |
| 出版事項: |
2023
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| 主題: | |
| オンライン･アクセス: | http://earchive.tpu.ru/handle/11683/132651 https://doi.org/10.3390/pharmaceutics15030939 |
| フォーマット: | 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669343 |
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| 200 | 1 | |a Antibacterial Activity and Cytocompatibility of Electrospun PLGA Scaffolds Surface-Modified by Pulsed DC Magnetron Co-Sputtering of Copper and Titanium |f A. D. Badaraev, M. I. Lerner, O. V. Bakina [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 89 tit.] | ||
| 330 | |a Biocompatible poly(lactide-co-glycolide) scaffolds fabricated via electrospinning are having promising properties as implants for the regeneration of fast-growing tissues, which are able to degrade in the body. The hereby-presented research work investigates the surface modification of these scaffolds in order to improve antibacterial properties of this type of scaffolds, as it can increase their application possibilities in medicine. Therefore, the scaffolds were surface-modified by means of pulsed direct current magnetron co-sputtering of copper and titanium targets in an inert atmosphere of argon. In order to obtain different amounts of copper and titanium in the resulting coatings, three different surface-modified scaffold samples were produced by changing the magnetron sputtering process parameters. The success of the antibacterial properties’ improvement was tested with the methicillin-resistant bacterium Staphylococcus aureus. In addition, the resulting cell toxicity of the surface modification by copper and titanium was examined using mouse embryonic and human gingival fibroblasts. As a result, the scaffold samples surface-modified with the highest copper to titanium ratio show the best antibacterial properties and no toxicity against mouse fibroblasts, but have a toxic effect to human gingival fibroblasts. The scaffold samples with the lowest copper to titanium ratio display no antibacterial effect and toxicity. The optimal poly(lactide-co-glycolide) scaffold sample is surface-modified with a medium ratio of copper and titanium that has antibacterial properties and is non-toxic to both cell cultures. | ||
| 461 | |t Pharmaceutics | ||
| 463 | |t Vol. 15, iss. 3 |v [939, 22 p.] |d 2023 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a electrospinning | |
| 610 | 1 | |a PLGA scaffolds | |
| 610 | 1 | |a pulsed DC magnetron co-sputtering | |
| 610 | 1 | |a copper-titanium thin film | |
| 610 | 1 | |a surface modification | |
| 610 | 1 | |a antibacterial activity | |
| 610 | 1 | |a cytotoxicity | |
| 610 | 1 | |a электропрядение | |
| 610 | 1 | |a импульсное магнетронное распыление | |
| 610 | 1 | |a тонкие пленки | |
| 610 | 1 | |a антибактериальная активность | |
| 610 | 1 | |a цитотоксичность | |
| 701 | 1 | |a Badaraev |b A. D. |c Physicist |c Engineer of Tomsk Polytechnic University |f 1995- |g Arsalan Dorzhievich |3 (RuTPU)RU\TPU\pers\46819 |9 22441 | |
| 701 | 1 | |a Lerner |b M. I. |c specialist in the field of mechanical engineering |c Professor of Tomsk Polytechnic University, Doctor of technical sciences |f 1956- |g Marat Izrailyevich |3 (RuTPU)RU\TPU\pers\31423 |9 15587 | |
| 701 | 1 | |a Bakina |b O. V. |c specialist in the field of medical technology |c researcher of Tomsk Polytechnic University |f 1979- |g Olga Vladimirovna |3 (RuTPU)RU\TPU\pers\34696 | |
| 701 | 1 | |a Sidelev |b D. V. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of Technical Sciences |f 1991- |g Dmitry Vladimirovich |y Tomsk |3 (RuTPU)RU\TPU\pers\34524 |9 17905 | |
| 701 | 0 | |a Tran Tuan Hoang |c specialist in the field of nuclear technologies |c engineer of Tomsk Polytechnic University |f 1993- |3 (RuTPU)RU\TPU\pers\47572 | |
| 701 | 1 | |a Krinitsyn |b M. G. |c specialist in the field of mechanical engineering |c engineer of Tomsk Polytechnic University |f 1992- |g Maksim Germanovich |3 (RuTPU)RU\TPU\pers\37439 | |
| 701 | 1 | |a Malashicheva |b A. B. |g Anna | |
| 701 | 1 | |a Cherempey |b E. G. |g Elena | |
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| 701 | 1 | |a Kozelskaya |b A. I. |c physicist |c Researcher at Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences |f 1985- |g Anna Ivanovna |3 (RuTPU)RU\TPU\pers\39663 |9 21044 | |
| 701 | 1 | |a Rutkowski |b S. |c chemist |c Research Engineer, Tomsk Polytechnic University, Ph.D |f 1981- |g Sven |3 (RuTPU)RU\TPU\pers\46773 |9 22409 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |3 (RuTPU)RU\TPU\pers\30855 | |
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