Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds; Molecules; Vol. 28, iss. 4

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds; Molecules; Vol. 28, iss. 4

Bibliografski detalji
Parent link:Molecules
Vol. 28, iss. 4.— 2023.— [1853, 13 p.]
Autor kompanije: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Daljnji autori: Krasnov V. P. Victor, Vozdvizhenskaya O. A. Olga, Baryshnikova M. A. Maria, Pershina A. G. Aleksandra Gennadievna, Musiyak V. V. Vera, Matveeva T. V. Tatyana, Nevskaya K. V. Kseniya, Brikunova O. Y. Olga, Gruzdev D. A. Dmitry, Levit G. A. Galina
Sažetak:Title screen
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 murine mammary carcinoma, COLO201 human colorectal adenocarcinoma, SNU-1 human gastric carcinoma, and HepG2 human hepatocellular carcinoma cells. Synthesis and study of structural analogs of these compounds made it possible to find that the presence of both a difluorobenzoxazine fragment and a purine residue bound via a linker of a certain length is crucial for the manifestation of the cytotoxic activity of this group of compounds. The study of the effect of the most promising compound on the cell cycle of the human tumor cell lines, the most sensitive and least sensitive to cytotoxic action (MDA-MB-231 breast adenocarcinoma and COLO201 colorectal adenocarcinoma, respectively), allows us to conclude that this compound is an inhibitor of DNA biosynthesis. The found group of purine conjugates may be of interest in the design of new antitumor agents.
Jezik:engleski
Izdano: 2023
Teme:
труды учёных ТПУ
электронный ресурс
purine
omega-amino acids
7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine
cytotoxicity
tumor cells
пурины
цитотоксичность
опухолевые клетки
Online pristup:https://doi.org/10.3390/molecules28041853
Format: Elektronički Poglavlje knjige
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=669215

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