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| 182 |
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0 |
|a b
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| 200 |
1 |
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|a Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
|f Sh. Akhmedov, S. Afanasyev, N. Beshchasna [et al.]
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| 203 |
|
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|a Text
|c electronic
|
| 320 |
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|a [References: 17 tit.]
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| 330 |
|
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|a The high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt–chromium (CoCr) alloy tubes, which are used for coronary stent manufacturing, were prepared with a coating of polylactic acid (PLA) which contained either modified or non-modified Fe@C NPs in a 5% by weight concentration. The tubes were implanted into an area of subcutaneous fat in Wistar rats, where changes in the histological structure and functional properties of the surrounding tissue were observed in the case of coatings modified with Fe@C NPs. For the ex vivo study, freshly explanted human atherosclerotic plaques were treated in the physiological solution with doses of modified Fe@C NPs, with mass equal to 5% or 25% relative to the plaques. This treatment resulted in the release of cholesterol-like compounds from the surface of the plaques into the solution, thus proving a pronounced destructive effect on the plaque structure. Chemically modified Fe@C NPs, when used as an anti-atherosclerosis agent, were able to activate the activity of macrophages, which could lead to the destruction of atherosclerotic plaques structures. These findings could prove the fabrication of next-generation vascular stents with built-in anti-atherosclerotic agents.
|
| 461 |
|
|
|t International Journal of Molecular Sciences
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| 463 |
|
|
|t Vol. 23, iss. 15
|v [8241, 12 p. ]
|d 2022
|
| 610 |
1 |
|
|a труды учёных ТПУ
|
| 610 |
1 |
|
|a электронный ресурс
|
| 610 |
1 |
|
|a atherosclerosis
|
| 610 |
1 |
|
|a atherosclerotic plaque
|
| 610 |
1 |
|
|a chemically modified carbon-coated iron nanoparticle
|
| 610 |
1 |
|
|a reverse cholesterol transport
|
| 610 |
1 |
|
|a macrophage
|
| 610 |
1 |
|
|a coronary stent
|
| 701 |
|
1 |
|a Akhmedov
|b Sh.
|g Shamil
|
| 701 |
|
1 |
|a Afanasyev
|b S.
|g Sergey
|
| 701 |
|
1 |
|a Beshchasna
|b N.
|g Natalia
|
| 701 |
|
1 |
|a Trusova
|b M. E.
|c organic chemist
|c Associate professor of Tomsk Polytechnic University, Candidate of chemical sciences
|f 1982-
|g Marina Evgenievna
|3 (RuTPU)RU\TPU\pers\31823
|9 15918
|
| 701 |
|
1 |
|a Stepanov
|b I.
|g Ivan
|
| 701 |
|
1 |
|a Rebenkova
|b M.
|g Mariya
|
| 701 |
|
1 |
|a Poletykina
|b E. Ya.
|c chemical technologist
|c research engineer at Tomsk Polytechnic University
|f 1998-
|g Ekaterina Yaroslavovna
|3 (RuTPU)RU\TPU\pers\47482
|
| 701 |
|
1 |
|a Vecherskiy
|b Yu.
|g Yuri
|
| 701 |
|
1 |
|a Tverdokhlebov
|b S. I.
|c physicist
|c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science
|f 1961-
|g Sergei Ivanovich
|3 (RuTPU)RU\TPU\pers\30855
|
| 701 |
|
1 |
|a Bolbasov
|b E. N.
|c physicist
|c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences
|f 1981-
|g Evgeny Nikolaevich
|3 (RuTPU)RU\TPU\pers\30857
|9 15103
|
| 701 |
|
1 |
|a Balakin
|b S.
|g Sascha
|
| 701 |
|
1 |
|a Opitz
|b J.
|g Jorg
|
| 701 |
|
1 |
|a Yermakov
|b A.
|g Anatoly
|
| 701 |
|
1 |
|a Kozlov
|b B.
|g Boris
|
| 712 |
0 |
2 |
|a Национальный исследовательский Томский политехнический университет
|b Исследовательская школа химических и биомедицинских технологий
|c (2017- )
|3 (RuTPU)RU\TPU\col\23537
|
| 801 |
|
0 |
|a RU
|b 63413507
|c 20230207
|g RCR
|
| 856 |
4 |
|
|u https://doi.org/10.3390/ijms23158241
|
| 942 |
|
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|c CF
|
