Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Bibliographic Details
Parent link:International Journal of Molecular Sciences
Vol. 23, iss. 16.— 2022.— [9093, 14 p. ]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Demin A. M. Alexander, Vakhrushev A. V. Aleksandr, Pershina A. G. Aleksandra Gennadievna, Valova M. S. Marina, Efimova L. V. Lina Viktorovna, Semchina A. A. Aleksandra, Uymin M. A. Mikhail Aleksandrovich, Minin A. S. Artem Sergeevich, Levit G. L. Galina, Krasnov V. P. Viktor, Charushin V. N. Valery
Summary:Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
Published: 2022
Subjects:
труды учёных ТПУ
электронный ресурс
magnetic nanoparticles
SiO2
PEG
doxorubicin
alternating magnetic field
tumor cells
drug-delivery
магнитные наночастицы
доксорубицин
переменное магнитное поле
опухолевые клетки
доставка
лекарства
Online Access:http://earchive.tpu.ru/handle/11683/74887
https://doi.org/10.3390/ijms23169093
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668787

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