Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

書誌詳細
Parent link:	International Journal of Molecular Sciences Vol. 23, iss. 16.— 2022.— [9093, 14 p. ]
団体著者:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
その他の著者:	Demin A. M. Alexander, Vakhrushev A. V. Aleksandr, Pershina A. G. Aleksandra Gennadievna, Valova M. S. Marina, Efimova L. V. Lina Viktorovna, Semchina A. A. Aleksandra, Uymin M. A. Mikhail Aleksandrovich, Minin A. S. Artem Sergeevich, Levit G. L. Galina, Krasnov V. P. Viktor, Charushin V. N. Valery
要約:	Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
出版事項:	2022
主題:	труды учёных ТПУ электронный ресурс magnetic nanoparticles SiO2 PEG doxorubicin alternating magnetic field tumor cells drug-delivery магнитные наночастицы доксорубицин переменное магнитное поле опухолевые клетки доставка лекарства
オンライン･アクセス:	http://earchive.tpu.ru/handle/11683/74887 https://doi.org/10.3390/ijms23169093
フォーマット:	電子媒体図書の章
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668787

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