Investigation of Antiblastic and Antibacterial Properties of Binuclear Platinum (II)-Interferon Conjugate; Current Bioactive Compounds; Vol. 18, iss. 7

Investigation of Antiblastic and Antibacterial Properties of Binuclear Platinum (II)-Interferon Conjugate; Current Bioactive Compounds; Vol. 18, iss. 7

Podrobná bibliografie
Parent link:Current Bioactive Compounds
Vol. 18, iss. 7.— 2022.— [P. 50-53]
Hlavní autor: Plotnikov E. V. Evgeny Vladimirovich
Korporativní autor: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Další autoři: Plotnikov V. M. Vladimir Mikhaylovich
Shrnutí:Title screen
Background: Multiple drug resistance of tumor cells is a serious challenge in modern medicine. Neoplastic diseases are often complicated by persistent bacterial infections, which impairs efficacy and the outcome of anticancer therapy. The development of new bifunctional drugs for the treatment of tumor growth and bacterial complications is an urgent task. Objective: The objective of this study was to evaluate the complex antiblastic and antibacterial properties of interferon-platinum conjugate in vitro. Materials and Methods: The coordination complex of dichloro-N,N,N,N-tetrakis-(2-aminoethyl)- 1,6-hexamethylenediaminobisplatin dichloride was used for production of conjugate with human a-interferon. The binding of a metal complex with protein was established by means of radiochemical neutron activation analysis. As test objects, we used lympholeukemic Jurkat cells line, human lymphocytes in reaction of lymphocyte blastic transformation and different strains of microorganisms, including Staphylococcus aureus and Pseudomonas aeruginosa. Results: Binuclear platinum human a-interferon conjugate has a significant dose-dependent antibacterial and antiproliferative suppressive effect on target cells and bacteria. Conclusion: The tested preparation can be of a certain interest in drug designing for rational antiblastic therapy, especially in the case of infectious complications. This conjugate can be a convenient platform for creating drugs for the complex therapy of oncological diseases with bacterial complications.
Режим доступа: по договору с организацией-держателем ресурса
Jazyk:angličtina
Vydáno: 2022
Témata:
электронный ресурс
труды учёных ТПУ
interferon
Jurkat cell
pseudomonas aeruginosa
staphylococcus aureus
metalloprotein conjugate
platinum
интерфероны
On-line přístup:https://doi.org/10.2174/1573407218666220112112008
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668727

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