Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity
| Parent link: | Biomaterials Advances Vol. 134.— 2022.— [112697, 12 p.] |
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| Institution som forfatter: | |
| Andre forfattere: | , , , , , , , , , , , |
| Summary: | Title screen The widespread of bacterial infections including biofilms drives the never-ending quest for new antimicrobial agents. Among the great variety of nanomaterials, carbon dots (CDs) are the most promising antibacterial material, but still require the adjustment of their surface properties for enhanced activity. In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria. CDs were modified by novel diazonium salts bearing tetraalkylammonium moieties (TAA) with different alkyl chains (C2, C4, C9, C12) for the optimization of antibacterial activity. Variation of the alkyl chain allows to reach the significant antibacterial effect for CDs-C9 towards Gram-positive Staphylococcus aureus (S. aureus) (MIC = 3.09 ± 1.10 μg mL−1) and Gram-negative Escherichia coli (E. coli) (MIC = 7.93 ± 0.17 μg mL−1) bacteria. The antibacterial mechanism of CDs-C9 is ascribed to the balance between the positive charge and hydrophobicity of the alkyl chains. TAA moieties are responsible for enhanced adherence on the bacterial cell membrane, its penetration and disturbance of physiological metabolism. CDs-C9 were not effective in the generation of reactive oxygen species excluding the oxidative damage mechanism. In addition, CDs-C9 effectively promoted the antibiofilm treatment of S. aureus and E. coli biofilms outperforming previously-reported CDs in terms of treatment duration and minimal inhibitory concentration. The good biocompatibility of CDs-C9 was demonstrated on mouse fibroblast (NIH/3T3), HeLa and U-87 MG cell lines for concentrations up to 256 μg mL−1. Collectively, our work highlights the correlation between the surface chemistry of CDs and their antimicrobial performance. |
| Sprog: | engelsk |
| Udgivet: |
2022
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| Fag: | |
| Online adgang: | https://doi.org/10.1016/j.msec.2022.112697 |
| Format: | Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668705 |
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| 200 | 1 | |a Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity |f E. V. Sviridova, A. Barras, A. Addad [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 80 tit.] | ||
| 330 | |a The widespread of bacterial infections including biofilms drives the never-ending quest for new antimicrobial agents. Among the great variety of nanomaterials, carbon dots (CDs) are the most promising antibacterial material, but still require the adjustment of their surface properties for enhanced activity. In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria. CDs were modified by novel diazonium salts bearing tetraalkylammonium moieties (TAA) with different alkyl chains (C2, C4, C9, C12) for the optimization of antibacterial activity. Variation of the alkyl chain allows to reach the significant antibacterial effect for CDs-C9 towards Gram-positive Staphylococcus aureus (S. aureus) (MIC = 3.09 ± 1.10 μg mL−1) and Gram-negative Escherichia coli (E. coli) (MIC = 7.93 ± 0.17 μg mL−1) bacteria. The antibacterial mechanism of CDs-C9 is ascribed to the balance between the positive charge and hydrophobicity of the alkyl chains. TAA moieties are responsible for enhanced adherence on the bacterial cell membrane, its penetration and disturbance of physiological metabolism. CDs-C9 were not effective in the generation of reactive oxygen species excluding the oxidative damage mechanism. In addition, CDs-C9 effectively promoted the antibiofilm treatment of S. aureus and E. coli biofilms outperforming previously-reported CDs in terms of treatment duration and minimal inhibitory concentration. The good biocompatibility of CDs-C9 was demonstrated on mouse fibroblast (NIH/3T3), HeLa and U-87 MG cell lines for concentrations up to 256 μg mL−1. Collectively, our work highlights the correlation between the surface chemistry of CDs and their antimicrobial performance. | ||
| 461 | |t Biomaterials Advances | ||
| 463 | |t Vol. 134 |v [112697, 12 p.] |d 2022 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a carbon dots | |
| 610 | 1 | |a diazonium chemistry | |
| 610 | 1 | |a tetraalkylammonium salts | |
| 610 | 1 | |a antibacterial activity | |
| 610 | 1 | |a biofilms | |
| 610 | 1 | |a углеродные точки | |
| 610 | 1 | |a тетраалкиламмониевые соли | |
| 610 | 1 | |a диазониевые соли | |
| 610 | 1 | |a антибактериальная активность | |
| 610 | 1 | |a биопленки | |
| 701 | 1 | |a Sviridova |b E. V. |c specialist in the field of chemical technology, petrochemistry and biotechnology |c engineer of Tomsk Polytechnic University |f 1994- |g Elizaveta Vitaljevna |3 (RuTPU)RU\TPU\pers\46149 | |
| 701 | 1 | |a Barras |b A. |g Alexandre | |
| 701 | 1 | |a Addad |b A. |g Ahmed | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |3 (RuTPU)RU\TPU\pers\32469 |9 16417 | |
| 701 | 1 | |a Di Martino |b A. |c organic chemist |c research of Tomsk Polytechnic University |f 1984- |g Antonio |3 (RuTPU)RU\TPU\pers\39440 |9 20983 | |
| 701 | 1 | |a Dominique |b D. |g Deresmes | |
| 701 | 1 | |a Nikiforova |b K. A. |c Chemical engineer |c Engineer of Tomsk Polytechnic University |f 1988- |g Ksenia Alekseevna |3 (RuTPU)RU\TPU\pers\44186 | |
| 701 | 1 | |a Trusova |b M. E. |c organic chemist |c Associate professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1982- |g Marina Evgenievna |3 (RuTPU)RU\TPU\pers\31823 |9 15918 | |
| 701 | 1 | |a Guselnikova |b O. A. |c chemist |c Researcher at Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1992- |g Olga Andreevna |3 (RuTPU)RU\TPU\pers\34478 |9 17861 | |
| 701 | 1 | |a Szunerits |b S. |g Sabine | |
| 701 | 1 | |a Postnikov |b P. S. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1984- |g Pavel Sergeevich |3 (RuTPU)RU\TPU\pers\31287 | |
| 701 | 1 | |a Boukherroub |b R. |g Rabah | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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