Printed asymmetric microcapsules: Facile loading and multiple stimuli-responsiveness; Biomaterials Advances; Vol. 136

Printed asymmetric microcapsules: Facile loading and multiple stimuli-responsiveness; Biomaterials Advances; Vol. 136

Մատենագիտական մանրամասներ
Parent link:Biomaterials Advances
Vol. 136.— 2022.— [212762, 16 p.]
Համատեղ հեղինակ: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Лаборатория плазменных гибридных систем
Այլ հեղինակներ: Kudryavtseva V. L. Valeriya Lvovna, Bukatin A. F. Anton Filippovich, Vyacheslavova E. A. Ekaterina Aleksandrovna, Gould J. David, Sukhorukov G. B. Gleb Borisovich
Ամփոփում:Title screen
Engineering of colloidal particles and capsules despite substantial progress is still facing a number of unsolved issues including low loading capacity, non-uniform size and shape of carriers, tailoring different functionalities and versatility to encapsulated cargo. In this work, we propose a method for defined-shaped functionally asymmetric polymer capsule fabrication based on a soft lithography approach. The developed capsules consist of two classes of polymers – the main part “cup” is made out of polyelectrolyte multilayers (PAH-PSS) and “lid” is made of biodegradable polyether (PLGA). Asymmetric capsules combine advantages from both traditional layer-by-layer capsules and recently developed printed “pelmeni” capsules. This combination provides stimuli-responsiveness due to polyelectrolyte multilayer properties differing from PLGA. The inner volume of capsules can be loaded with a variety of active compounds and the capsule's geometry is defined due to the soft-lithography method. Capsules have a core-shell structure and monodisperse size distribution. Three methods to trigger cargo release have been demonstrated, namely temperature treatment, ultrasonication and pH shift. Steroidal drug dexamethasone was used to illustrate the applicability of the systems for triggered drug release. The application of proposed asymmetric capsules includes but is not limited to pharmacology, diagnostics, sensors, micro- and nanoreactors and chemical actuators.
Լեզու:անգլերեն
Հրապարակվել է: 2022
Խորագրեր:
электронный ресурс
труды учёных ТПУ
layer-by-layer
controlled release
polymer capsules
polylactic acid
soft lithography
контролируемые величины
полимолочная кислота
мягкая литография
Առցանց հասանելիություն:https://doi.org/10.1016/j.bioadv.2022.212762
Ձևաչափ: Էլեկտրոնային Գրքի գլուխ
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668649

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