Printed asymmetric microcapsules: Facile loading and multiple stimuli-responsiveness; Biomaterials Advances; Vol. 136
| Parent link: | Biomaterials Advances Vol. 136.— 2022.— [212762, 16 p.] |
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| Údar corparáideach: | |
| Rannpháirtithe: | , , , , |
| Achoimre: | Title screen Engineering of colloidal particles and capsules despite substantial progress is still facing a number of unsolved issues including low loading capacity, non-uniform size and shape of carriers, tailoring different functionalities and versatility to encapsulated cargo. In this work, we propose a method for defined-shaped functionally asymmetric polymer capsule fabrication based on a soft lithography approach. The developed capsules consist of two classes of polymers – the main part “cup” is made out of polyelectrolyte multilayers (PAH-PSS) and “lid” is made of biodegradable polyether (PLGA). Asymmetric capsules combine advantages from both traditional layer-by-layer capsules and recently developed printed “pelmeni” capsules. This combination provides stimuli-responsiveness due to polyelectrolyte multilayer properties differing from PLGA. The inner volume of capsules can be loaded with a variety of active compounds and the capsule's geometry is defined due to the soft-lithography method. Capsules have a core-shell structure and monodisperse size distribution. Three methods to trigger cargo release have been demonstrated, namely temperature treatment, ultrasonication and pH shift. Steroidal drug dexamethasone was used to illustrate the applicability of the systems for triggered drug release. The application of proposed asymmetric capsules includes but is not limited to pharmacology, diagnostics, sensors, micro- and nanoreactors and chemical actuators. |
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
2022
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| Ábhair: | |
| Rochtain ar líne: | https://doi.org/10.1016/j.bioadv.2022.212762 |
| Formáid: | Leictreonach Caibidil leabhair |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668649 |
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| 200 | 1 | |a Printed asymmetric microcapsules: Facile loading and multiple stimuli-responsiveness |f V. L. Kudryavtseva, A. F. Bukatin, E. A. Vyacheslavova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 57 tit.] | ||
| 330 | |a Engineering of colloidal particles and capsules despite substantial progress is still facing a number of unsolved issues including low loading capacity, non-uniform size and shape of carriers, tailoring different functionalities and versatility to encapsulated cargo. In this work, we propose a method for defined-shaped functionally asymmetric polymer capsule fabrication based on a soft lithography approach. The developed capsules consist of two classes of polymers – the main part “cup” is made out of polyelectrolyte multilayers (PAH-PSS) and “lid” is made of biodegradable polyether (PLGA). Asymmetric capsules combine advantages from both traditional layer-by-layer capsules and recently developed printed “pelmeni” capsules. This combination provides stimuli-responsiveness due to polyelectrolyte multilayer properties differing from PLGA. The inner volume of capsules can be loaded with a variety of active compounds and the capsule's geometry is defined due to the soft-lithography method. Capsules have a core-shell structure and monodisperse size distribution. Three methods to trigger cargo release have been demonstrated, namely temperature treatment, ultrasonication and pH shift. Steroidal drug dexamethasone was used to illustrate the applicability of the systems for triggered drug release. The application of proposed asymmetric capsules includes but is not limited to pharmacology, diagnostics, sensors, micro- and nanoreactors and chemical actuators. | ||
| 461 | |t Biomaterials Advances | ||
| 463 | |t Vol. 136 |v [212762, 16 p.] |d 2022 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a layer-by-layer | |
| 610 | 1 | |a controlled release | |
| 610 | 1 | |a polymer capsules | |
| 610 | 1 | |a polylactic acid | |
| 610 | 1 | |a soft lithography | |
| 610 | 1 | |a контролируемые величины | |
| 610 | 1 | |a полимолочная кислота | |
| 610 | 1 | |a мягкая литография | |
| 701 | 1 | |a Kudryavtseva |b V. L. |c physicist |c Engineer of Tomsk Polytechnic University |f 1993- |g Valeriya Lvovna |3 (RuTPU)RU\TPU\pers\38564 | |
| 701 | 1 | |a Bukatin |b A. F. |g Anton Filippovich | |
| 701 | 1 | |a Vyacheslavova |b E. A. |g Ekaterina Aleksandrovna | |
| 701 | 1 | |a Gould |b J. |g David | |
| 701 | 1 | |a Sukhorukov |b G. B. |c chemist |c The Head of the Laboratory of Tomsk Polytechnic University, Candidate of physical and mathematical sciences |f 1969- |g Gleb Borisovich |3 (RuTPU)RU\TPU\pers\37353 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа ядерных технологий |b Лаборатория плазменных гибридных систем |3 (RuTPU)RU\TPU\col\23381 |
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