Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate; Molbank; Vol. 2022, iss. 4

Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate; Molbank; Vol. 2022, iss. 4

التفاصيل البيبلوغرافية
Parent link:Molbank
Vol. 2022, iss. 4.— 2022.— [M1451, 7 p.]
مؤلف مشترك: Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
مؤلفون آخرون: Kovrizhina A. R. Anastasia Ruslanovna, Kolpakova A. A. Alina Andreevna, Kuznetsov A. A. Andrey Aleksandrovich, Khlebnikov A. I. Andrey Ivanovich
الملخص:Title screen
Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, Compound 2 is potentially highly bioavailable and has the prospective to be used as the main component for the development of anti-inflammatory drugs.
اللغة:الإنجليزية
منشور في: 2022
الموضوعات:
электронный ресурс
труды учёных ТПУ
dicarboxylic acid derivative
tryptanthrin
isomerism
DFT
ADME
الوصول للمادة أونلاين:https://doi.org/10.3390/M1451
التنسيق: الكتروني فصل الكتاب
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668640

مواد مشابهة

مواد مشابهة