Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate; Molbank; Vol. 2022, iss. 4
| Источник: | Molbank Vol. 2022, iss. 4.— 2022.— [M1451, 7 p.] |
|---|---|
| Автор-организация: | |
| Другие авторы: | , , , |
| Примечания: | Title screen Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, Compound 2 is potentially highly bioavailable and has the prospective to be used as the main component for the development of anti-inflammatory drugs. |
| Язык: | английский |
| Опубликовано: |
2022
|
| Предметы: | |
| Online-ссылка: | https://doi.org/10.3390/M1451 |
| Формат: | xMaterials Электронный ресурс Статья |
| Запись в KOHA: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668640 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 668640 | ||
| 005 | 20250630133930.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\39877 | ||
| 035 | |a RU\TPU\network\39257 | ||
| 090 | |a 668640 | ||
| 100 | |a 20230113d2022 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate |f A. R. Kovrizhina, A. A. Kolpakova, A. A. Kuznetsov, A. I. Khlebnikov | |
| 203 | |a Текст |c электронный | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 40 tit.] | ||
| 330 | |a Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, Compound 2 is potentially highly bioavailable and has the prospective to be used as the main component for the development of anti-inflammatory drugs. | ||
| 461 | |t Molbank | ||
| 463 | |t Vol. 2022, iss. 4 |v [M1451, 7 p.] |d 2022 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a dicarboxylic acid derivative | |
| 610 | 1 | |a tryptanthrin | |
| 610 | 1 | |a isomerism | |
| 610 | 1 | |a DFT | |
| 610 | 1 | |a ADME | |
| 701 | 1 | |a Kovrizhina |b A. R. |c biotechnology specialist |c Research Engineer of Tomsk Polytechnic University |f 1995- |g Anastasia Ruslanovna |3 (RuTPU)RU\TPU\pers\46608 |9 22266 | |
| 701 | 1 | |a Kolpakova |b A. A. |g Alina Andreevna | |
| 701 | 1 | |a Kuznetsov |b A. A. |g Andrey Aleksandrovich | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |3 (RuTPU)RU\TPU\pers\33927 |9 17500 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа новых производственных технологий |b Научно-образовательный центр Н. М. Кижнера |3 (RuTPU)RU\TPU\col\23556 |
| 801 | 2 | |a RU |b 63413507 |c 20230113 |g RCR | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.3390/M1451 |z https://doi.org/10.3390/M1451 | |
| 942 | |c CF | ||