Electrospun polycaprolactone scaffolds loaded with a 1,4-naphthoquinone derivative for anticancer therapy

Electrospun polycaprolactone scaffolds loaded with a 1,4-naphthoquinone derivative for anticancer therapy

Bibliographic Details
Parent link:Materials Letters
Vol. 327.— 2022.— [133062, 4 p.]
Corporate Authors: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга, Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Other Authors: Danilenko N. V. Nadezhda Viktorovna, Bolbasov E. N. Evgeny Nikolaevich, Khlebnikov A. I. Andrey Ivanovich, Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Tverdokhlebov S. I. Sergei Ivanovich, Quinn M. T. Mark
Summary:Title screen
The development of bioresorbable scaffolds with anticancer properties for use in tissue repair after surgical resection of tumors is important. Naphthoquinones with high anticancer activity are promising compounds for creating anticancer scaffolds. Thus, electrospun polycaprolactone (PCL) scaffolds embedded with different concentrations of 2-chloro-3-((4-hydroxyphenyl)amino)-1,4-naphthoquinonone (NQCP4) were fabricated without changing the technological parameters of scaffold formation. Loading NQCP4 into the spinning solution at concentrations of 10 to 50 ?g/mL did not cause changes in the structure, strength, or wettability of the scaffold. However, increasing NQCP4 concentrations in the spinning solution enhanced anticancer properties of the scaffolds in vitro. Thus, the use of NQCP4 makes it possible to obtain promising PCL scaffolds for tissue repair, which are in demand for surgical resection of malignant neoplasms, while still maintaining the technological advantages of “classical” electrospinning technology.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2022
Subjects:
электронный ресурс
труды учёных ТПУ
1,4-Naphthoquinone derivative
electrospun scaffold
polycaprolactone
anticancer
Online Access:https://doi.org/10.1016/j.matlet.2022.133062
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668500

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