Oxa-spirocycles: synthesis, properties and applications; Chemical Science; Vol. 12, iss. 34

Oxa-spirocycles: synthesis, properties and applications; Chemical Science; Vol. 12, iss. 34

Bibliographic Details
Parent link:	Chemical Science Vol. 12, iss. 34.— 2021.— [P. 11294-11305]
Corporate Author:	Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Other Authors:	Fominova E. E. Ekaterina Evgenjevna, Djyachuk T. Taras, Granat D. Dmitry, Kuznetsova A. S. Anastasiya Sergeevna
Summary:	Title screen A general approach to a new generation of spirocyclic molecules – oxa-spirocycles – was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studied in vivo.
Language:	English
Published:	2021
Subjects:	электронный ресурс труды учёных ТПУ
Online Access:	https://doi.org/10.1039/D1SC00658D
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668044

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