Oxa-spirocycles: synthesis, properties and applications; Chemical Science; Vol. 12, iss. 34
| Parent link: | Chemical Science Vol. 12, iss. 34.— 2021.— [P. 11294-11305] |
|---|---|
| مؤلف مشترك: | |
| مؤلفون آخرون: | , , , |
| الملخص: | Title screen A general approach to a new generation of spirocyclic molecules – oxa-spirocycles – was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studied in vivo. |
| اللغة: | الإنجليزية |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1039/D1SC00658D |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668044 |
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| 200 | 1 | |a Oxa-spirocycles: synthesis, properties and applications |f E. E. Fominova , T. Djyachuk, D. Granat, A. S. Kuznetsova | |
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| 300 | |a Title screen | ||
| 320 | |a [References: 42 tit.] | ||
| 330 | |a A general approach to a new generation of spirocyclic molecules – oxa-spirocycles – was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studied in vivo. | ||
| 461 | |t Chemical Science | ||
| 463 | |t Vol. 12, iss. 34 |v [P. 11294-11305] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
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| 701 | 1 | |a Djyachuk |b T. |g Taras | |
| 701 | 1 | |a Granat |b D. |g Dmitry | |
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