Oxa-spirocycles: synthesis, properties and applications
| Parent link: | Chemical Science Vol. 12, iss. 34.— 2021.— [P. 11294-11305] |
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| 団体著者: | |
| その他の著者: | , , , |
| 要約: | Title screen A general approach to a new generation of spirocyclic molecules – oxa-spirocycles – was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studied in vivo. |
| 言語: | 英語 |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1039/D1SC00658D |
| フォーマット: | 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668044 |
| 要約: | Title screen A general approach to a new generation of spirocyclic molecules – oxa-spirocycles – was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studied in vivo. |
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| DOI: | 10.1039/D1SC00658D |