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668014 |
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20250826101841.0 |
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|a (RuTPU)RU\TPU\network\39225
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| 035 |
|
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|a RU\TPU\network\39034
|
| 090 |
|
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|a 668014
|
| 100 |
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|a 20220527d2022 k||y0rusy50 ba
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| 101 |
0 |
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|a eng
|
| 135 |
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|a drcn ---uucaa
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| 181 |
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0 |
|a i
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| 182 |
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0 |
|a b
|
| 200 |
1 |
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|a Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications
|f A. Pryadko, V. V. Botvin, Yu. R. Mukhortova [et al.]
|
| 203 |
|
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|a Text
|c electronic
|
| 320 |
|
|
|a [References: 75 tit.]
|
| 330 |
|
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|a Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe3O4) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe3O4 scaffolds submicron-sized Fe3O4 particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio–0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C. The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the decrease in melting temperature to 168–169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe3O4). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candidates for usage in biomedical applications.
|
| 461 |
|
|
|t Polymers
|
| 463 |
|
|
|t Vol. 14, iss. 3
|v [529, 17 p. ]
|d 2022
|
| 610 |
1 |
|
|a труды учёных ТПУ
|
| 610 |
1 |
|
|a электронный ресурс
|
| 610 |
1 |
|
|a magnetoactive scaffold
|
| 610 |
1 |
|
|a poly-3-hydroxybutyrate
|
| 610 |
1 |
|
|a magnetite
|
| 610 |
1 |
|
|a composite
|
| 610 |
1 |
|
|a core-shell structure
|
| 610 |
1 |
|
|a магнетит
|
| 610 |
1 |
|
|a структура
|
| 701 |
|
1 |
|a Pryadko
|b A.
|c Specialist in the field of nuclear technologies
|c Research Engineer of Tomsk Polytechnic University
|f 1995-
|g Artyom
|3 (RuTPU)RU\TPU\pers\46948
|
| 701 |
|
1 |
|a Botvin
|b V. V.
|c chemist
|c Senior Researcher of Tomsk Polytechnic University, Candidate of chemical sciences
|f 1991-
|g Vladimir Viktorovich
|3 (RuTPU)RU\TPU\pers\47211
|
| 701 |
|
1 |
|a Mukhortova
|b Yu. R.
|c Chemical engineer
|c Engineer of Tomsk Polytechnic University
|f 1976-
|g Yulia Ruslanovna
|3 (RuTPU)RU\TPU\pers\46606
|9 22264
|
| 701 |
|
1 |
|a Pary (Pariy)
|b I. O.
|c physicist
|c engineer of Tomsk Polytechnic University
|f 1995-
|g Igor Olegovich
|3 (RuTPU)RU\TPU\pers\45219
|
| 701 |
|
1 |
|a Vagner
|b D. V.
|g Dmitry Viktorovich
|
| 701 |
|
1 |
|a Laktionov
|b P. P.
|g Pavel Petrovich
|
| 701 |
|
1 |
|a Chernonosova
|b V. S.
|g Vera Sergeevna
|
| 701 |
|
1 |
|a Chelobanov
|b B. P.
|g Boris Pavlovich
|
| 701 |
|
1 |
|a Chernozem
|b R. V.
|c physicist
|c Associate Professor of Tomsk Polytechnic University
|f 1992-
|g Roman Viktorovich
|3 (RuTPU)RU\TPU\pers\36450
|9 19499
|
| 701 |
|
1 |
|a Surmeneva
|b M. A.
|c specialist in the field of material science
|c engineer-researcher of Tomsk Polytechnic University, Associate Scientist
|f 1984-
|g Maria Alexandrovna
|3 (RuTPU)RU\TPU\pers\31894
|9 15966
|
| 701 |
|
1 |
|a Kholkin
|b A. L.
|c physicist
|c Director of the International Research Center for PMEM of the Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences
|f 1954-
|g Andrei Leonidovich
|3 (RuTPU)RU\TPU\pers\47207
|
| 701 |
|
1 |
|a Surmenev
|b R. A.
|c physicist
|c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences
|f 1982-
|g Roman Anatolievich
|3 (RuTPU)RU\TPU\pers\31885
|9 15957
|
| 712 |
0 |
2 |
|a Национальный исследовательский Томский политехнический университет
|b Исследовательская школа химических и биомедицинских технологий
|b Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
|3 (RuTPU)RU\TPU\col\24957
|
| 712 |
0 |
2 |
|a Национальный исследовательский Томский политехнический университет
|b Исследовательская школа химических и биомедицинских технологий
|c (2017- )
|3 (RuTPU)RU\TPU\col\23537
|
| 801 |
|
0 |
|a RU
|b 63413507
|c 20220527
|g RCR
|
| 856 |
4 |
|
|u https://doi.org/10.3390/polym14030529
|
| 942 |
|
|
|c CF
|
