Calcium Chelidonate: Semi-Synthesis, Crystallography, and Osteoinductive Activity In Vitro and In Vivo; Pharmaceuticals; Vol. 14, iss. 6

Calcium Chelidonate: Semi-Synthesis, Crystallography, and Osteoinductive Activity In Vitro and In Vivo; Pharmaceuticals; Vol. 14, iss. 6

Bibliographic Details
Parent link:Pharmaceuticals
Vol. 14, iss. 6.— 2021.— [579, 14 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Avdeeva E. Elena, Porokhova E. Ekaterina, Khlusov I. A. Igor Albertovich, Rybalova T. Tatyana, Shults E. Elvira, Litvinova L. S. Larisa Sergeevna, Shupletsova V. V. Valeria, Khaziakhmatova O. G. Olga Gennadjevna, Sukhodolo I. Irina, Belousov M. V. Mikhail Valerievich
Summary:Title screen
Calcium chelidonate [Ca(ChA)(H2O)3]n was obtained by semi-synthesis using natural chelidonic acid. The structure of the molecular complex was determined by X-ray diffraction analysis. The asymmetric unit of [Ca(ChA)(H2O)3]n includes chelidonic acid coordinated through three oxygen atoms, and three water ligands. The oxygen atoms of acid and oxygen atoms of water from each asymmetric unit are also coordinated to the calcium of another one, forming an infinite linear complex. Calcium geometry is close to the trigonal dodecahedron (D2d). The intra-complex hydrogen bonds additionally stabilize the linear species, which are parallel to the axis. In turn the linear species are packed into the 3D structure through mutual intercomplex hydrogen bonds. The osteogenic activity of the semi-synthetic CaChA was studied in vitro on 21-day hAMMSC culture and in vivo in mice using ectopic (subcutaneous) implantation of CaP-coated Ti plates saturated in vitro with syngeneic bone marrow. The enhanced extracellular matrix ECM mineralization in vitro and ectopic bone tissue formation in situ occurred while a water solution of calcium chelidonate at a dose of 10 mg/kg was used. The test substance promotes human adipose-derived multipotent mesenchymal stromal/stem cells (hAMMSCs), as well as mouse MSCs to differentiate into osteoblasts in vitro and in vivo, respectively. Calcium chelidonate is non-toxic and can stimulate osteoinductive processes.
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
calcium chelidonate
semi-synthesis
X-ray diffraction analysis
osteogenic activity
рентгеноструктурный анализ
Online Access:https://doi.org/10.3390/ph14060579
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667909

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