Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field; Colloids and Surfaces B: Biointerfaces; Vol. 206

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Parent link:	Colloids and Surfaces B: Biointerfaces Vol. 206.— 2021.— [111931, 12 p.]
Tác giả của công ty:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Tác giả khác:	Ilyasov A. I. Artem Ivanovich, Nizamov T. R. Timur Radikovich, Naumenko V. A. Viktor Alekseevich, Garanina A. S. Anastasiya Sergeevna, Vodopjyanov S. S. Stepan Sergeevich, Nikitin A. S. Aleksey Sergeevich, Pershina A. G. Aleksandra Gennadievna, Chernysheva A. S. Anastasiya Sergeevna, Kan Yu. V. Yuliya Vadimovna, Mogilnikov P. S. Pavel Sergeevich, Metelkina O. N. Olga Nikolaevna, Shchetinin I. V. Igor Viktorovich, Savchenko A. G. Aleksandr Grigorjevich, Mazhuga A. G. Aleksandr Georgievich, Abakumov M. A. Maksim Artemovich
Tóm tắt:	Title screen This work is devoted to studying the effects of non-magnetic shell coating on nanoparticles in a low frequency alternating magnetic field (LF AMF) on tumor cells in vitro. Two types of iron oxide nanoparticles with the same magnetic core with and without silica shells were synthesized. Nanoparticles with silica shells significantly decreased the viability of PC3 cancer cells in a low frequency alternating magnetic field according to the cytotoxicity test, unlike uncoated nanoparticles. We showed that cell death results from the intracellular membrane integrity failure, and the calcium ions concentration increase with the subsequent necrosis. Transmission electron microscopy images showed that the uncoated silica nanoparticles are primarily found in an aggregated form in cells. We believe that uncoated nanoparticles lose their colloidal stability in an acidic endosomal environment after internalization into the cell due to surface etching and the formation of aggregates. As a result, they encounter high endosomal macromolecular viscosity and become unable to rotate efficiently. We assume that effective rotation of nanoparticles causes cell death. In turn, silica shell coating increases nanoparticles stability, preventing aggregation in endosomes. Thus, we propose that the colloidal stability of magnetic nanoparticles inside cells is one of the key factors for effective magneto-mechanical actuation. Режим доступа: по договору с организацией-держателем ресурса
Ngôn ngữ:	Tiếng Anh
Được phát hành:	2021
Những chủ đề:	электронный ресурс труды учёных ТПУ magnetic nanoparticles low frequency alternating magnetic field cytotoxicity magneto-mechanical actuation core-shell silica shell магнитные наночастицы низкочастотные поля низкочастотные магнитные поля цитотоксичность
Truy cập trực tuyến:	https://doi.org/10.1016/j.colsurfb.2021.111931
Định dạng:	Điện tử Chương của sách
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667866