Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field; Colloids and Surfaces B: Biointerfaces; Vol. 206
| Parent link: | Colloids and Surfaces B: Biointerfaces Vol. 206.— 2021.— [111931, 12 p.] |
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| Ente Autore: | |
| Altri autori: | , , , , , , , , , , , , , , |
| Riassunto: | Title screen This work is devoted to studying the effects of non-magnetic shell coating on nanoparticles in a low frequency alternating magnetic field (LF AMF) on tumor cells in vitro. Two types of iron oxide nanoparticles with the same magnetic core with and without silica shells were synthesized. Nanoparticles with silica shells significantly decreased the viability of PC3 cancer cells in a low frequency alternating magnetic field according to the cytotoxicity test, unlike uncoated nanoparticles. We showed that cell death results from the intracellular membrane integrity failure, and the calcium ions concentration increase with the subsequent necrosis. Transmission electron microscopy images showed that the uncoated silica nanoparticles are primarily found in an aggregated form in cells. We believe that uncoated nanoparticles lose their colloidal stability in an acidic endosomal environment after internalization into the cell due to surface etching and the formation of aggregates. As a result, they encounter high endosomal macromolecular viscosity and become unable to rotate efficiently. We assume that effective rotation of nanoparticles causes cell death. In turn, silica shell coating increases nanoparticles stability, preventing aggregation in endosomes. Thus, we propose that the colloidal stability of magnetic nanoparticles inside cells is one of the key factors for effective magneto-mechanical actuation. Режим доступа: по договору с организацией-держателем ресурса |
| Lingua: | inglese |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://doi.org/10.1016/j.colsurfb.2021.111931 |
| Natura: | MixedMaterials Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667866 |
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| 200 | 1 | |a Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field |f A. I. Ilyasov, T. R. Nizamov, V. A. Naumenko [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 42 tit.] | ||
| 330 | |a This work is devoted to studying the effects of non-magnetic shell coating on nanoparticles in a low frequency alternating magnetic field (LF AMF) on tumor cells in vitro. Two types of iron oxide nanoparticles with the same magnetic core with and without silica shells were synthesized. Nanoparticles with silica shells significantly decreased the viability of PC3 cancer cells in a low frequency alternating magnetic field according to the cytotoxicity test, unlike uncoated nanoparticles. We showed that cell death results from the intracellular membrane integrity failure, and the calcium ions concentration increase with the subsequent necrosis. Transmission electron microscopy images showed that the uncoated silica nanoparticles are primarily found in an aggregated form in cells. We believe that uncoated nanoparticles lose their colloidal stability in an acidic endosomal environment after internalization into the cell due to surface etching and the formation of aggregates. As a result, they encounter high endosomal macromolecular viscosity and become unable to rotate efficiently. We assume that effective rotation of nanoparticles causes cell death. In turn, silica shell coating increases nanoparticles stability, preventing aggregation in endosomes. Thus, we propose that the colloidal stability of magnetic nanoparticles inside cells is one of the key factors for effective magneto-mechanical actuation. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Colloids and Surfaces B: Biointerfaces | ||
| 463 | |t Vol. 206 |v [111931, 12 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a magnetic nanoparticles | |
| 610 | 1 | |a low frequency alternating magnetic field | |
| 610 | 1 | |a cytotoxicity | |
| 610 | 1 | |a magneto-mechanical actuation | |
| 610 | 1 | |a core-shell | |
| 610 | 1 | |a silica shell | |
| 610 | 1 | |a магнитные наночастицы | |
| 610 | 1 | |a низкочастотные поля | |
| 610 | 1 | |a низкочастотные поля | |
| 610 | 1 | |a низкочастотные магнитные поля | |
| 610 | 1 | |a цитотоксичность | |
| 701 | 1 | |a Ilyasov |b A. I. |g Artem Ivanovich | |
| 701 | 1 | |a Nizamov |b T. R. |g Timur Radikovich | |
| 701 | 1 | |a Naumenko |b V. A. |g Viktor Alekseevich | |
| 701 | 1 | |a Garanina |b A. S. |g Anastasiya Sergeevna | |
| 701 | 1 | |a Vodopjyanov |b S. S. |g Stepan Sergeevich | |
| 701 | 1 | |a Nikitin |b A. S. |g Aleksey Sergeevich | |
| 701 | 1 | |a Pershina |b A. G. |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |f 1981- |g Aleksandra Gennadievna |3 (RuTPU)RU\TPU\pers\32466 |9 16414 | |
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| 701 | 1 | |a Shchetinin |b I. V. |g Igor Viktorovich | |
| 701 | 1 | |a Savchenko |b A. G. |g Aleksandr Grigorjevich | |
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| 701 | 1 | |a Abakumov |b M. A. |g Maksim Artemovich | |
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