The effect of different sizes of cross-linked fibers of biodegradable electrospun poly(ε-caprolactone) scaffolds on osteogenic behavior in a rat model in vivo; Journal of Applied Polymer Science; Vol. 139, iss. 22

The effect of different sizes of cross-linked fibers of biodegradable electrospun poly(ε-caprolactone) scaffolds on osteogenic behavior in a rat model in vivo; Journal of Applied Polymer Science; Vol. 139, iss. 22

Podrobná bibliografie
Parent link:Journal of Applied Polymer Science
Vol. 139, iss. 22.— 2022.— [52244, 11 p.]
Korporativní autor: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Další autoři: Surmenev R. A. Roman Anatolievich, Ivanov A. N. Aleksey, Saveljeva M. S. Mariya Sergeevna, Kiriyazi T. S. Tatjyana, Fedonnikov A. S. Aleksandr, Surmeneva M. A. Maria Alexandrovna
Shrnutí:Title screen
A variety of biodegradable polymer scaffolds serving the purpose of mimicking the extracellular matrix have been studied; however, no effective recipe has yet been developed for scaffold pore size and overall percent porosity, which are optimal for cell penetration in vitro and tissue growth in vivo. Thus, this study reports the effect of poly(ε-caprolactone) (PCL) fiber size and scaffold porosity on the osteogenic behavior of scaffolds in a rat model in vivo. It was revealed that scaffolds with an average fiber size of 9.2 μm, and 4.05 μm, and combination of 0.6 μm submicrofibres (upper layer) with 9.2 μm microfibres (bottom layer) in hybrid two-layer scaffolds behave significantly differently with respect to macrophage reactions and tissue regeneration in a rat model in vivo. Poor macrophage response at implantation tests into the bone tissue in vivo reveals the advantages of microfibrous PCL scaffolds with a fiber size of 4.05 μm and hybrid scaffolds with submicro- and microfibres for stimulation of reparative osteogenesis over microfibrous scaffolds with a fiber size of 9.2 μm. The combination of submicro- and microfibrous layers in hybrid scaffolds provides an opportunity to control the shape and density of bone trabeculae during regeneration processes in vivo.
Режим доступа: по договору с организацией-держателем ресурса
Jazyk:angličtina
Vydáno: 2022
Témata:
электронный ресурс
труды учёных ТПУ
biomaterials
biomedical applications
electrospinning
structure-property relationships
биоматериалы
биомедицинские технологии
электропрядение
On-line přístup:https://doi.org/10.1002/app.52244
Médium: xMaterials Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667824

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