AgNPs Targeting the Drug Resistance Problem of Staphylococcus aureus: Susceptibility to Antibiotics and Efflux Effect; Pharmaceutics; Vol. 14, iss. 4

AgNPs Targeting the Drug Resistance Problem of Staphylococcus aureus: Susceptibility to Antibiotics and Efflux Effect; Pharmaceutics; Vol. 14, iss. 4

Bibliographic Details
Parent link:Pharmaceutics
Vol. 14, iss. 4.— 2022.— [763, 15 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Nefedova E. Ekaterina, Shkil N. Nikolay, Vazquez-Gomez R. L. Roberto Luna, Garibo D. Diana, Pestryakov A. N. Aleksey Nikolaevich, Bogdanchikova N. Nina
Summary:Title screen
The present work presents translational research with application of AgNPs targeting the global drug resistance problem. In vivo fieldwork was carried out with 400 breeding farm cows sick with a serous mastitis. Ex vivo results revealed that after cow treatment with LactobayTM (a mixture of antibiotic drugs) the susceptibility to 31 antibiotics of S. aureus isolates from cow breast secretion decreased by 25%, while after treatment with Argovit-CTM silver nanoparticles S. aureus susceptibility increased by 11%. The portion of isolates with an efflux effect leading to elimination of antibiotics from S. aureus after Lactobay-treatment resulted in a 15% increase, while Argovit-C-treatment led to a 17.5% decrease. The obtained results showed that mastitis treatments with Argovit-CTM AgNPs can partially restore the activity of antibiotics towards S. aureus and shorten the duration of mastitis treatment by 33%.
Language:English
Published: 2022
Subjects:
электронный ресурс
труды учёных ТПУ
AgNPs
lactobay
S. aureus
efflux effect
стафилококки
антибиотики
лечение
Online Access:https://doi.org/10.3390/pharmaceutics14040763
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667765

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